The study investigates the relationship between benign prostate hypertrophy (BPH) size and prostate cancer (PCa) occurrence, suggesting that increased pressure from a growing transition zone (TZ) may lead to atrophy in the peripheral zone (PZ), where PCa typically develops.
MRI scans of 204 male patients were analyzed, revealing a weak inverse correlation between total prostate volume (TPV) and peripheral zone thickness (PZT), with significantly different results when dividing patients into lower and higher TPV groups.
The findings indicate that as BPH grows, it compresses the PZ tissue, potentially providing a protective effect against the development of prostate cancer.