Intersectional Care for Asian American and Pacific Islander Youth With Sexual or Gender Minority Identities in the Acute Psychiatric Care Setting.

Youth who hold both Asian American and Pacific Islander (AAPI) and sexual or gender minority (SGM) identities are frequently overlooked and underserved, and experience intersecting forms of discrimination, interpersonal stressors, and structural barriers. Amid heightened anti-AAPI and anti-SGM violence, these populations are particularly vulnerable to poor mental health outcomes. In 2023, over half of AAPI SGM reported experiences of depression, anxiety, and gender-based discrimination, and nearly half reported racial abuse.

Postoperative Pain Management Among Dominican and American Health-Care Providers: A Qualitative Analysis.

Background: U.S. practitioners have prescribed opioid analgesics increasingly in recent years, contributing to what has been declared an opioid epidemic by the U.

Pain management among Dominican patients with advanced osteoarthritis: a qualitative study.

Background: Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission Operation Walk Boston (OpWalk) to the Dominican Republic have observed that Dominican patients require substantially less opioid medication following TJR than US patients. We conducted a qualitative study to investigate approaches to pain management and expectations for postoperative recovery in patients with advanced arthritis undergoing TJR in the Dominican Republic.

CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.

Emerging resistance to first-line antimalarial combination therapies threatens malaria treatment and the global elimination campaign. Improved therapeutic strategies are required to protect existing drugs and enhance treatment efficacy. We report that the piperazine-containing compound ACT-451840 exhibits single-digit nanomolar inhibition of the Plasmodium falciparum asexual blood stages and transmissible gametocyte forms.