Epithelioid malignant mesothelioma metastatic to the skin: A case report and review of the literature.

Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic mesothelioma, and histologic examination is often challenging because the tumor closely mimics other primary and metastatic neoplasms.

Multilevel symmetric neuropathic pruritus (MSNP) presenting as recalcitrant "generalized" pruritus.

Background: Chronic itch is a disruptive and disabling condition that can lead to psychological stress and depression.

Objective: We sought to describe an entity of generalized, symmetric, neuropathic pruritus, which we term "multilevel symmetric neuropathic pruritus," and offer possible explanations accounting for its pathogenesis.

Methods: A case series of 14 patients was evaluated at academic institutions from 2011 to 2015.