Publications by authors named "Rachel E Szeghy"
Article Synopsis
- Elevated levels of brain injury biomarkers were mostly observed in older adults with moderate-to-severe COVID-19 symptoms, but there is limited research on younger individuals experiencing mild symptoms.
- A study measured the plasma levels of neurofilament light (NfL), glial fibrillary acidic protein (GFAP), tau, and UCHL1 in 12 young adults diagnosed with mild COVID-19 over a period of four months.
- Results showed that mild COVID-19 does not significantly elevate these biomarkers compared to healthy individuals, although there was a notable increase in UCHL1 levels at three months post-diagnosis, and sex differences in biomarker levels were observed.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit acute and long-term effects on the myocardium among survivors, yet effects among otherwise healthy young adults remains unclear. Young adults with mild symptoms of SARS-CoV-2 (8M/8F, age: 21 ± 1 years, BMI: 23.5 ± 3.
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- SARS-CoV-2 infection can cause vascular dysfunction, but it's unclear how long these effects last in young adults with mild symptoms.
- A study tracked vascular function and inflammatory markers in 16 young adults over 6 months after SARS-CoV-2 infection, noting improvements in macrovascular function but no changes in microvascular function.
- The findings indicate that while there may be some recovery in larger blood vessels, young adults still face potential long-term cardiovascular risks after mild COVID-19.
Article Synopsis
- Acute SARS-CoV-2 infection significantly increases muscle sympathetic nerve activity (MSNA) and affects blood pressure responses in young adults, but the long-term effects remain unclear.
- A study tracked MSNA, blood pressure, and heart rate in SARS-CoV-2 positive young adults over 6 months, revealing that resting blood pressure levels decreased while MSNA and heart rate remained stable.
- The findings suggest cardiovascular health impairments following SARS-CoV-2 infection may improve over time, although changes in blood pressure are not linked directly to sympathetic nervous activity.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can increase arterial stiffness 3-4 wk following infection, even among young, healthy adults. However, the long-term impacts of SARS-CoV-2 infection on cardiovascular health and the duration of recovery remain unknown. The purpose of this study was to elucidate potential long-lasting effects of SARS-CoV-2 infection on markers of arterial stiffness among young adults during the 6 mo following infection.
View Article and Find Full Text PDFNew Findings: What is the central question of this study? We sought to investigate whether carotid stiffness, carotid intima-media thickness and the aortic augmentation index are altered in young adults 3-4 weeks after contraction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with young healthy adults. What is the main finding and its importance? We found that carotid stiffness, Young's modulus and the aortic augmentation index were greater in young adults who tested positive for SARS-CoV-2 compared with healthy young adults. These findings provide additional evidence for detrimental effects of SARS-CoV-2 on young adult vasculature, which might have implications for cardiovascular health.
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