Publications by authors named "Rachel E Andrew"
Background: Despite data suggesting safety and efficacy in ulcerative colitis patients treated with inpatient infliximab, prior studies did not focus on patients with extensive colitis, the group at highest risk for requiring surgery.
Methods: This was a single center, retrospective study (2008-2015) of consecutive patients who required admission because of severe extensive ulcerative colitis defined by preoperative symptoms and computed tomography scans and postoperative histology. Patients admitted for high-dose steroids were compared with steroid refractory inpatients provided with one or two infusions of infliximab.
Update on medical and surgical options for patients with acute severe ulcerative colitis: What is new?
World J Gastrointest Surg
September 2016
Article Synopsis
- Acute severe ulcerative colitis (UC) requires a team approach between gastroenterologists and colorectal surgeons, with initial treatment typically involving intravenous steroids; if ineffective, surgery may be necessary.
- Although complications from emergency colectomy have decreased, prolonged medical treatments can worsen patient health, leading to worse surgical outcomes when surgery becomes unavoidable.
- The review highlights the importance of balancing medical therapies and timely surgical intervention, emphasizing that colectomy remains essential for severe cases, with various reconstructive options available post-surgery.