The Complex Role of the Microbiome in Non-Small Cell Lung Cancer Development and Progression.

In recent years, there has been a growing interest in the relationship between microorganisms in the surrounding environment and cancer cells. While the tumor microenvironment predominantly comprises cancer cells, stromal cells, and immune cells, emerging research highlights the significant contributions of microbial cells to tumor development and progression. Although the impact of the gut microbiome on treatment response in lung cancer is well established, recent investigations indicate complex roles of lung microbiota in lung cancer.

Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis.

Liquid biopsies have emerged as a promising tool for the detection of metastases as well as local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a patient's blood, urine, or other body fluids for the detection of biomarkers, including circulating tumor cells or tumor-derived DNA/RNA that have been shed into the bloodstream. Studies have shown that liquid biopsies can detect lung cancer metastases with high accuracy and sensitivity, even before they are visible on imaging scans.

Advances in the Molecular Landscape of Lung Cancer Brain Metastasis.

Lung cancer is one of the most frequent tumors that metastasize to the brain. Brain metastasis (BM) is common in advanced cases, being the major cause of patient morbidity and mortality. BMs are thought to arise via the seeding of circulating tumor cells into the brain microvasculature.

Utilising a novel surveillance system to enhance field screening activities for the leishmaniases.

Over the last decade, an arbovirus surveillance system based on the preservation of nucleic acids (RNA/DNA) has been developed using Flinders Technology Associates (FTA) cards. Soaked in honey, FTA cards are applied in the field to detect arboviruses expectorated during mosquito sugar feeding. This technique has been shown to be inexpensive and efficient, and the implementation of this system for detecting parasites could be of international importance.

Utilising a novel surveillance system to investigate species of () (Diptera: Ceratopogonidae) as the suspected vectors of (Kinetoplastida: Trypanosomatidae) in the Darwin region of Australia.

Up until recently, Australia was considered free of due to the absence of phlebotomine sandfly species (Diptera: Phlebotominae) known to transmit parasites in other parts of the world. The discovery of () (Kinetoplastida: Trypanosomatidae) in Northern Australia sparked questions as to the existence of alternative vectors of . This has added to the complexity of fully understanding the parasite's interaction with its vector, which is known to be very specific.

Crocodilepox Virus Evolutionary Genomics Supports Observed Poxvirus Infection Dynamics on Saltwater Crocodile ().

Saltwater crocodilepox virus (SwCRV), belonging to the genus , are large DNA viruses posing an economic risk to Australian saltwater crocodile () farms by extending production times. Although poxvirus-like particles and sequences have been confirmed, their infection dynamics, inter-farm genetic variability and evolutionary relationships remain largely unknown. In this study, a poxvirus infection dynamics study was conducted on two farms.

Salivary shedding of HHV-8 in people infected or not by human immunodeficiency virus 1.

Background: Human herpesvirus 8 (HHV-8), the main agent involved in the etiopathogenesis of Kaposi's sarcoma (KS) is primarily transmitted through sexual contact. The potential of saliva as a source of HHV-8 transmission remains unclear. The purpose of this work was to determine the frequency of HHV-8 detection in saliva of HIV-infected individuals and their family contacts.

[Understanding the meanings of ischemic chest pain of patients admitted in the emergency room].

Nursing professionals who work in emergency units are constantly facing patients with ischemic chest pain. This study aimed at understanding the meanings of patients with ischemic chest pain when they are in the emergency room. It is a study with qualitative approach that was carried with ten patients admitted in an emergency room in a private hospital in the south zone of São Paulo city.