Publications by authors named "Rachel Biondo-Simoes"
Introduction: valproic acid (VPA), an epigenetic drug, has potential for the treatment of neoplasms. Its effects on the healing of the peritoneal-musculo-aponeurotic plane (PMA) of the abdominal wall are studied.
Method: sixty Wistar rats were allocated into two groups: experimental (VPA) and control (0.
Purpose: to recognize the effects of valproic acid (VPA), an epigenetic drug, on the bladder healing process, in rats.
Method: twenty male Wistar rats were divided in two groups: experimental (A), treated with VPA (150mg/Kg/day), and control (B) with 0.9% sodium chloridrate.
Purpose: To recognize the effects of valproic acid (VPA), an epigenetic drug, on the skin healing process.
Methods: Sixty male Wistar rats were divided into two groups: the experiment treated with VPA (100 mg/kg/day); and the control, with 0.9% sodium chloride by gavage.
Purpose: Histologically evaluate the effects of low frequency electrical stimulation in the treatment of Achilles tendon injuries in rats.
Methods: Thirty-four rats underwent Achilles tendon tenotomy and tenorrhaphy. They were randomly allocated in two groups.
Purpose: To evaluate the effects of low-frequency electric stimulation on biomechanics following surgical treatment of the Achilles tendon in rats.
Methods: Forty-two rats were divided into two groups. One was given electric stimulation and the other was not.
Purpose: To evaluate the fibrosis induced by four different meshes: Marlex®, Parietex Composite®, Vicryl® and Ultrapro®.
Methods: Histological cutouts of abdominal wall were analyzed with polarized light 28 days after the meshes implants and colorized by picrosirius to identify the intensity of collagen types I and III, and their maturation index.
Results: When the four groups were compared, the total collagen area analyzed was bigger in groups A and D, with no difference between them.
Introduction: Treatment for obesity essentially has to do with weight loss, which can be achieved through surgical procedures. Despite the considerable rise in the number of such procedures, the relationship between obesity and the healing process has not been totally clarified.
Purpose: To investigate abdominal wound healing in obese Wistar rats on the seventh and fourteenth days following a laparotomy.
Objective: To study the inflammatory reaction and deposition of collagen in the healing of cutaneous injuries under the influence of nicotine.
Methods: The scars of abdominal injuries in rats were analyzed, which had been treated with nicotine, 2 mg/kg/d, and compared with those of control rats. Treatment was begun seven days prior to operation and was maintained for seven or fourteen days after surgery.
Purpose: To study the collagen density and the population of fibroblasts in cutaneous injuries in rats under the influence of nicotine.
Methods: The scars of abdominal wounds in rats were analyzed. 2 mg/kg/d of nicotine was administered to the animals in the experiment group and the solution used as a vehicle for the animals in the control group.
Introduction: Despite the significant advances in the knowledge of the healing process, there is a limited number of studies demonstrating the relationships of this healing with ageing and elevated levels of glycemia.
Purpose: To evaluate the effects of ageing and hyperglycemia on the healing of colonic anastomosis.
Methods: 138 young and old male rats were utilized.
Background: The influence of hypothyroidism in liver regeneration has been a controversial opinions.
Purpose: The aim of this study is to identify the relationship between hypothyroidism and liver regeneration in rats.
Methods: Forty male Wistar rats divided into two groups of 20 specimens each.
Purpose: The aging of the population has led to an increased number of interventions in elderly patients, with hypothyroidism, even at the subclinical level, being a common situation among these patients. The objective of the present study was to determine the influence of hypothyroidism on the healing process of colon anastomoses in aged rats.
Methods: 96 male Wistar rats were used, 48 of them young and 48 old.