Automated disposable small scale reactor for high throughput bioprocess development: a proof of concept study.

The acceleration of bioprocess development for biologics and vaccines can be enabled by automated high throughput technologies. This will alleviate the significant resource burden from the multi-factorial statistical experimentation required for controlling product quality attributes of complex biologics. Recent technology advances have improved clone evaluation and screening, but have struggled to combine the scale down criteria required for both high cell density cell culture and microbial processes, with sufficient automation and disposable technologies to accelerate process development.

A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need.

The pharmaceutical and biotech industries face continued pressure to reduce development costs and accelerate process development. This challenge occurs alongside the need for increased upstream experimentation to support quality by design initiatives and the pursuit of predictive models from systems biology. A small scale system enabling multiple reactions in parallel (n ≥ 20), with automated sampling and integrated to purification, would provide significant improvement (four to fivefold) to development timelines.

Single limb performance following contralateral bimanual limb training.

Recent studies on intermanual transfer of reaching movements suggest that this transfer is conducted over an "extrinsic" coordinate system. We hypothesize that training reaching movements in a force field with both hands at the same time, in the same position (bimanual grip) will be more beneficial in promoting transfer of the learned skill to the dominant hand than training the unimpaired limb on the same movements in the same force field since the representation of the movement should be invariant of the limb. However, unlike intermanual transfer, bimanual transfer has the potential to involve infinite number of actuator combinations, or joint configurations, interfering with consistent transfer.