Publications by authors named "Rachel A Frenner"

Article Synopsis
  • NPIs significantly reduced asthma exacerbations and viral infections in pediatric patients during their enforcement from March 2020 to December 2022.
  • A total of 5,758 asthma exacerbations were recorded, with a 50% decline during NPIs, while 87% of the 70,682 respiratory tests returned positive for pathogens but showed decreased rates for some viruses.
  • After the NPIs ended, asthma exacerbations returned to pre-pandemic levels, and an unexpected spike in respiratory syncytial virus infections highlighted the importance of ongoing monitoring.
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Unlabelled: Non-pharmacologic interventions (NPIs), such as universal masking, implemented during the SARS-CoV-2 pandemic have reduced respiratory infections among children. This study evaluated the impact of NPIs on infections in children, analyzing data from two hospitals in Arkansas and examining age-related differences and co-infections with other respiratory viruses. The study was approved by the Institutional Review Board and included patients (≤18 years) with upper respiratory tract symptoms.

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Introduction: Non-pharmacologic interventions (NPIs), such as universal masking, implemented during the SARS-CoV-2 pandemic have reduced respiratory infections among children. This study focuses on evaluating the impact of NPIs on infections in children, analyzing data from two hospitals in Arkansas, and examining age-related differences and coinfections with other viruses.

Methods: The study was approved by the Institutional Review Board and included patients aged ≤18 years with upper respiratory tract symptoms.

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An eleven-year-old tested positive for SARS-CoV-2 Lambda variant. Sequencing was performed on the Oxford Nanopore and the Illumina NextSeq 500. Both platforms identified all 7 of the synonymous mutations in the sample, while all 28 nonsynonymous mutations were identified from Oxford Nanopore and 20 nonsynonymous mutations were identified from Illumina.

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