Publications by authors named "Rached N"
Article Synopsis
- Herpes zoster (HZ) significantly impacts individual and public health, and a study analyzed clinical and laboratory data from 520 hospitalized HZ patients to identify key prognostic indicators.* ! -
- Results showed that systemic immune inflammatory biomarkers (like NLR and PIV) were much higher in HZ patients than healthy individuals, with absolute eosinopenia being a strong predictor for herpes zoster ophthalmicus (HZO).* ! -
- Key findings linked immunosuppression to a higher risk of herpes encephalitis and longer hospital stays, while not receiving intravenous antiviral therapy increased the likelihood of postherpetic neuralgia.* !
Article Synopsis
- Neoadjuvant and adjuvant therapies are becoming increasingly important in treating cutaneous melanoma (CM), but there is still a need for better prognostic tools to identify patients at high risk.
- Recent evidence suggests that liver scores could serve as potential prognostic indicators across various tumor types, prompting an investigation into their relevance for CM prognosis.
- A study involving 423 patients demonstrated that while tumor thickness and ulceration were key predictors of survival across all stages, liver scores like the APRI showed significant associations with survival outcomes specifically in earlier stages (I and II) of melanoma.
Article Synopsis
- * Significant findings include higher neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV) in SOCV patients compared to healthy controls, along with specific predictors of disease severity and hospitalization length.
- * Key results show that upper extremity manifestations suggest milder disease, while older age and lower serum C3 levels predict longer hospital stays and higher recurrence rates, highlighting the importance of these factors in patient prognosis.
Introduction: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a poor prognosis, which only improved with the introduction of immunotherapies. An MCC prediction model with high diagnostic accuracy is lacking. The aim was to develop an MCC prognostic score (MCC-PS) based on combinations of previously proposed risk factors.
View Article and Find Full Text PDFHidradenitis suppurativa (HS) is a debilitating, chronic inflammatory disease associated with multiple triggers. As the world struggles with the global COVID-19 pandemic, it is important to review the trigger factors for chronically ill HS patients during the COVID-19 pandemic. This work investigates the self-described trigger factors of HS patients that emerged during the COVID-19 outbreak.
View Article and Find Full Text PDFArticle Synopsis
- Hidradenitis suppurativa (HS) is a chronic inflammatory condition that significantly increases the risk of various cancers, with the risk reaching up to 50% in patients.
- A systematic review examined 443 initial publications, identifying 25 studies that showed a correlation between the severity of HS and the likelihood of specific malignancies like oropharyngeal, colorectal, and skin cancers.
- Complicated malignant transformations can occur in severe HS cases, leading to cutaneous squamous cell carcinoma (cSCC), but the underlying mechanisms for these changes are still not fully understood.
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, primarily affecting older and immunocompromised individuals, prompting increased attention to immunotherapy and vaccines as treatment options.
- - Recent research includes identifying 10 articles and 9 ongoing clinical trials focused on vaccines for MCC, with most studies being in early phases of development.
- - Various vaccine strategies are being explored, including DNA, synthetic peptide vaccines, RNA-based vaccines, oncolytic viruses, and combinations with immunotherapy, though it may take time for a vaccine to be approved for clinical use.
Article Synopsis
- The study focuses on two types of immune complex vasculitides in adults: IgA small vessel vasculitis (aIgA-SVV) and non-IgA small vessel vasculitis (non-IgA-SVV).
- Researchers analyzed clinical and laboratory data from 29 patients with aIgA-SVV and 53 with non-IgA-SVV to identify differences in their conditions.
- Key findings revealed that patients with aIgA-SVV showed higher rates of proteinuria and haematuria, while non-IgA-SVV patients had a higher platelet-to-lymphocyte ratio, indicating notable clinical distinctions between the two groups.
Hidradenitis suppurativa (HS) is a chronic skin disease that can have an association with endocrine disorders. There is conflicting information in the literature regarding the role of the thyroid gland in HS. This study aimed to close this knowledge gap and investigate how thyroid disease is involved in patients with HS.
View Article and Find Full Text PDFBackground: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that is highly correlated with obesity. Haptoglobin serum levels have recently been recognized as an important biomarker linking obesity with chronic inflammation.
Objective: To compare haptoglobin with previously proposed serum biomarkers for the determination of disease severity in HS patients.
Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for improving CWs.
View Article and Find Full Text PDFMerkel cell carcinoma (MCC) is a highly malignant skin tumor that occurs mainly in elderly and/or immunosuppressed patients. MCC prognosis has been significantly improved by the introduction of immune checkpoint inhibitor treatment. Recently, blood-based biomarkers have been investigated that can potentially predict the outcome of MCC patients.
View Article and Find Full Text PDFBackground: Even in the novel immunotherapy era, Merkel cell carcinoma (MCC) remains challenging in its treatment. Apart from Merkel cell polyomavirus (MCPyV) associated MCC, this cancer is linked in about 20% of cases to ultraviolet-induced mutational burden frequently causing aberrations in Notch and PI3K/AKT/mTOR signalling pathways. The recently developed agent GP-2250 is capable to inhibit growth of cells of different cancers, including pancreatic neuroendocrine tumors.
View Article and Find Full Text PDFHidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients.
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