PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin.

The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle cell anemia and β-thalassemia. Despite the physiological and clinical relevance of this switch, its posttranscriptional regulation is poorly understood.

Unmasking the conversation on masks: Natural language processing for topical sentiment analysis of COVID-19 Twitter discourse.

In this exploratory study, we scrutinize a database of over one million tweets collected from March to July 2020 to illustrate public attitudes towards mask usage during the COVID-19 pandemic. We employ natural language processing, clustering and sentiment analysis techniques to organize tweets relating to mask-wearing into high-level themes, then relay narratives for each theme using automatic text summarization. In recent months, a body of literature has highlighted the robustness of trends in online activity as proxies for the sociological impact of COVID-19.

By the Book: An Analysis of Adolescents with Autism Spectrum Condition Co-constructing Fictional Narratives with Peers.

In this discourse analytic study, we examine interactions between adolescents with autism spectrum condition (ASC) and their typically developing (TD) peers during the construction of fictional narratives within a group intervention context. We found participants with ASC contributed fewer narrative-related turns at talk than TD participants. The groups organized the activity as a means to subvert moral and social norms, and youth with ASC participated in negotiating new norms with varying degrees of success.

Repetition, response mobilization, and face: Analysis of group interactions with a 19-year-old with Asperger syndrome.

Unlabelled: This Conversation Analytic study examined the talk of an adolescent with Asperger syndrome (under previously used diagnostic criteria), Nathan, as he interacts with peers in a small group setting. We focused on Nathan's repetition aimed at pursuing response, and rely on analytical frameworks including response mobilization, face-work, and agreement preference. We found that while Nathan's repetitions resembled 'topic perseveration' previously described in the literature, they showed evidence of interactional awareness as they were employed when peers offered little or no response to his original utterance.