Publications by authors named "Rachael Saunders"
The developmental origins of health and disease hypothesis suggest early-life environment impacts health outcomes throughout the life course. In particular, epigenetic marks, including DNA methylation, are thought to be key mechanisms through which environmental exposures programme later-life health. Adequate maternal folate status before and during pregnancy is essential in the protection against neural tube defects, but data are emerging that suggest early-life folate exposures may also influence neurocognitive outcomes in childhood and, potentially, thereafter.
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- - This study examined 52 liver biopsies from 28 adult patients post-transplant, focusing on the occurrence and characteristics of sinusoidal fibrosis (SF) and pericellular fibrosis (PCF) in the tissue samples.
- - The results showed that SF was present in 69.2% of the biopsies, often in centrilobular areas, while PCF was observed in 13.5% of samples, specifically those with centrilobular fibrosis (CLF).
- - Key findings suggested that the development of SF may be influenced by the age of the liver graft and oxidative stress, whereas PCF correlates with hepatocyte ballooning and inflammation in centrilobular regions.