Publications by authors named "Rachael Mi Jung Choi"
Nat Commun
September 2015
Article Synopsis
- Cells that survive crises can become cancerous, often by reactivating telomerase, but some use a different method called alternative lengthening of telomeres (ALT).
- Research in Caenorhabditis elegans shows that ALT survivors can escape sterility by duplicating certain genomic regions across telomeres, leading to genomic changes.
- These regions, termed 'Template for ALT' (TALT), are characterized by telomere-like sequences and vary between different genetic backgrounds, suggesting a model for how ancestral duplications prepare these regions for telomere incorporation during ALT activation.
