Publications by authors named "Rachael M Vacassenno"
The effects of doxapram and its potential interactions with K2P channels in experimental model preparations.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
November 2024
Article Synopsis
- - K2P channels, which help maintain cell resting membrane potentials, are usually open and can be influenced by their surroundings; they are categorized by various factors like pharmacology and pH sensitivity.
- - Research indicates that acidic conditions can depolarize neurons and muscle fibers, possibly due to the blockage of K2P channels, specifically one subtype that is sensitive to acidity.
- - In experiments with doxapram, a known respiratory aid that blocks acid-sensitive K2P channels, results showed varied effects on Drosophila and crawfish muscle and nerve tissues, suggesting different K2P channel subtypes in these species, warranting further investigation.
Bacterial lipopolysaccharide hyperpolarizes the membrane potential and is antagonized by the K2p channel blocker doxapram.
Comp Biochem Physiol C Toxicol Pharmacol
April 2023
Exposure of Drosophila skeletal muscle to bacterial lipopolysaccharides (LPS) rapidly and transiently hyperpolarizes membrane potential. However, the mechanism responsible for hyperpolarization remains unclear. The resting membrane potential of the cells is maintained through multiple mechanisms.
View Article and Find Full Text PDFThe effects of doxapram (blocker of K2p channels) on resting membrane potential and synaptic transmission at the Drosophila neuromuscular junction.
Comp Biochem Physiol C Toxicol Pharmacol
January 2023
The resting membrane potential of most cells is maintained by potassium K2p channels. The pharmacological profile and distribution of various K2p channel subtypes in organisms are still being investigated. The Drosophila genome contains 11 subtypes; however, their function and expression profiles have not yet been determined.
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