Publications by authors named "Rachael Julia Yuenyinn Tan"
Article Synopsis
- Tumor-associated neutrophils (TANs) vary in function depending on the type of cancer, with their role being more significant in metabolic dysfunction-related liver cancer than in viral-related liver cancer.* -
- In metabolic dysfunction-associated hepatocellular carcinoma (MASH-related HCC), specific TANs (SiglecFhi) promote tumor growth and immune evasion by enhancing stemness and inhibiting the immune response.* -
- Targeting SiglecFhi TANs can improve the effectiveness of immunotherapy, as their removal increases cancer cell recognition and correlates with poor patient outcomes due to resistance to treatment.*
Patients with type 2 diabetes (T2D) are more susceptible to severe respiratory viral infections, but the underlying mechanisms remain elusive. Here, we show that patients with T2D and coronavirus disease 2019 (COVID-19) infections, and influenza-infected T2D mice, exhibit defective T helper 1 (Th1) responses, which are an essential component of anti-viral immunity. This defect stems from intrinsic metabolic perturbations in CD4 T cells driven by hyperglycemia.
View Article and Find Full Text PDFBackground: Depression is a severe neuropsychiatric disorder that affects more than 264 million people worldwide. The efficacy of conventional antidepressants are barely adequate and many have side effects. Hericium erinaceus (HE) is a medicinal mushroom that has been reported to have therapeutic potential for treating depression.
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