Publications by authors named "Rachael Inder"
Metastasis to regional lymph nodes is an important and early event in many tumors. Vascular endothelial growth factor-C (VEGF-C), VEGF-D and their receptor VEGFR-3, play a role in tumor spread via the lymphatics, although the timing of their involvement is not understood. In contrast, VEGFR-2, activated by VEGF-A, VEGF-C and VEGF-D, is a mediator of angiogenesis and drives primary tumor growth.
View Article and Find Full Text PDFTumor metastasis to lymph nodes is a key indicator of patient survival, and is enhanced by the neo-lymphatics induced by tumor-secreted VEGF-C or VEGF-D, acting via VEGFR-3 signalling. These targets constitute important avenues for anti-metastatic treatment. Despite this new understanding, clinical observations linking metastasis with tumor depth or location suggest that lymphangiogenic growth factors are not the sole determinants of metastasis.
View Article and Find Full Text PDFArticle Synopsis
- The lymphatic network helps move fluids, cells, and big molecules back into the bloodstream.
- Researchers have found important growth factors and markers that help us understand how lymphatic vessels grow and work.
- Studying these growth factors is important because they play a role in diseases like cancer and lymphoedema, and understanding them could help create new treatments.