Publications by authors named "Rachael E Rogers"
Diethylstilbestrol (DES) is an estrogenic endocrine disrupting chemical (EDC) that was prescribed to millions of pregnant women worldwide, leading to increased rates of infertility in the exposed offspring. We have previously demonstrated that this reduced fertility persists for multiple generations in the mouse. However, how altered ovarian function contributes to this infertility is unknown.
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- * DES, used by pregnant women from 1940 to 1970, had harmful reproductive effects on offspring, leading to increased infertility, pregnancy complications, and reproductive cancers in exposed women, with potential impacts on subsequent generations.
- * Research on gestating mice revealed that maternal DES exposure negatively affected reproductive health in female descendants for at least three generations, showing reduced pregnancy rates, altered puberty timing, and changes in anogenital distance, raising concerns