Publications by authors named "Rachael E Clifford"
Myoferlin: A Potential Marker of Response to Radiation Therapy and Survival in Locally Advanced Rectal Cancer.
Int J Radiat Oncol Biol Phys
November 2024
Purpose: Patients with locally advanced rectal cancer often require neoadjuvant chemoradiation therapy to downstage the disease, but the response is variable with no predictive biomarkers. We have previously revealed through proteomic profiling that myoferlin is associated with response to radiation therapy. The aims of this study were to further validate this finding and explore the potential for myoferlin to act as a prognostic and/or therapeutic target.
View Article and Find Full Text PDFArticle Synopsis
- - Tranexamic acid (TXA) is beneficial in reducing blood loss and the need for blood transfusions in patients undergoing elective abdominal and pelvic cancer surgeries.
- - A systematic review of 12 studies showed that those receiving TXA had significantly lower blood loss and were less likely to require red blood cell transfusions compared to those who didn't receive TXA.
- - The use of TXA did not increase the risk of venous thromboembolism, but more research is needed to understand its effectiveness across different types of cancer surgeries.
Aim: Benign anastomotic strictures following colorectal surgical resection are a commonly under-reported complication in up to 30% of patients, with a significant impact upon quality of life. In this systematic review, we aim to assess the utility of endoscopic techniques in avoiding the need for surgical reintervention.
Method: A literature search was performed for published full text articles using the PubMed, Cochrane and Scopus databases.
Background: Laparoscopic cholecystectomy is one of the most frequently performed operations in the United Kingdom, commonly due to symptomatic gallstones. Delay between diagnosis and definitive surgical intervention often leads to a significant readmission rate, growing financial burden and increased complexity of the ultimate surgical intervention. Resource reallocation and reduced operational capacity during the coronavirus disease 2019 (COVID-19) pandemic has led to an impending waiting list crisis.
View Article and Find Full Text PDFPrevious work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer. We aimed to assess the radiosensitising effect of biological and pharmacological manipulation of AC and elucidate the underlying mechanism. AC manipulation in three colorectal cancer cell lines (HT29, HCT116 and LIM1215) was achieved using siRNA and plasmid overexpression.
View Article and Find Full Text PDFAim: Anastomotic leak (AL) after colorectal resection is associated with increased rates of morbidity and mortality: potential permanent stoma formation, increased local recurrence, reduced cancer-related survival, poor functional outcomes and associated quality of life. Techniques to reduce leak rates are therefore highly sought.
Method: A literature search was performed for published full text articles using PubMed, Cochrane and Scopus databases with a focus on colorectal surgery 1990-2020.