Publications by authors named "Rachael C L Smith"
Cell division, differentiation and function are largely dependent on accurate proteome composition and regulated gene expression. To control this, protein synthesis is an intricate process governed by upstream signalling pathways. Eukaryotic translation is a multistep process and can be separated into four distinct phases: initiation, elongation, termination and recycling of ribosomal subunits.
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- Research using mouse models and organoids shows that the KRAS G12D mutation alters translation processes, leading to increased c-MYC protein expression through the MNK/eIF4E pathway.
- Targeting this pathway can make KRAS mutant cancers more responsive to rapamycin and is linked to poor patient survival, indicating a potential treatment strategy for a specific patient group.