FTO inhibits UPR-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes.

As a nucleic acid demethylase, Fat and obesity associated gene (FTO) plays a vital role in modulating adipose metabolism. However, it is still unknown how FTO affects apoptosis in adipocytes. In this study, we found that overexpression of FTO inhibited the expression of pro-apoptosis factors Caspase-3, Caspase-9 and Bax and mitochondrial unfolded protein response (UPR) markers HSP60 and ClpP in vivo and in vitro.

Occurrence of Dirofilaria immitis in Stray Dogs from Nepal.

Background: Nematodes of the genus Dirofilaria are widespread vector-borne helminths (VBH) of veterinary relevance. Dirofilariosis caused by D. immitis is frequently diagnosed in dogs often showing a severe clinical condition known as heartworm disease.