A decision support tool for early detection of knee OsteoArthritis using X-ray imaging and machine learning: Data from the OsteoArthritis Initiative.

This paper presents a fully developed computer aided diagnosis (CAD) system for early knee OsteoArthritis (OA) detection using knee X-ray imaging and machine learning algorithms. The X-ray images are first preprocessed in the Fourier domain using a circular Fourier filter. Then, a novel normalization method based on predictive modeling using multivariate linear regression (MLR) is applied to the data in order to reduce the variability between OA and healthy subjects.