The effect of trapidil and bevacizumab on tracheal anastomotic wound healing.

Background: Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses.

Objective: We aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection.

Materials And Methods: We evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7).