Effectiveness of a single versus repeated administration of trimetazidine in the protection against warm ischemia/reperfusion injury of rat liver.

Background/aim: The aim of this study was to compare the effects of single and repeated trimetazidine (TMZ) administration against warm hepatic ischemia/reperfusion (I/R) injury and to explore the possible mechanisms affected by TMZ.

Materials And Methods: Wistar rats were divided into 4 groups (n = 6). Sham: rats were subjected to dissection.