Oral isotretinoin in photoaging: clinical and histopathological evidence of efficacy of an off-label indication.

Background: Despite evidences of the beneficial clinical effects of oral isotretinoin in the treatment of cutaneous photoaging, scientific evidences are still scarce, mainly supported by histopathological and morphometric studies.

Objectives: To analyse possible clinical and morphological changes resulting from the treatment of photoaging with oral isotretinoin.

Methods: Thirty female patients, aged 40 to 55 years, phototypes II to IV, with moderate to severe photoaging were randomly assigned to two groups of 15 each.

Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy.

Hydroquinone is the first choice of topical bleaching agents used in treatment of melasma. In Brazil, hydroquinone is widely prescribed by physicians and often used by patients without a prescription. The principal adverse effects of its chronic use are confetti-like depigmentation and exogenous ochronosis.