Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression.

Objective: Serious non-AIDS disease events (SNAE) are experienced disproportionately by immunologic non-responders (INRs), HIV-infected individuals who do not restore CD4 T cells in blood despite effective viral suppression. We aimed to characterize the inflammatory biomarker profile of the INR phenotype.

Methods: Blinded cross-sectional cohort study comparing markers of immune activation and gut homing between INR and non-INR individuals.