Publications by authors named "Raakhee Ramesh"
Article Synopsis
- Targeted biologic therapies, such as adalimumab, can provoke the creation of antidrug antibodies (ADA), leading to treatment failures in immune-mediated diseases.
- This study focused on identifying genetic variations that make certain patients more likely to develop ADA against adalimumab, particularly in psoriasis patients on their first treatment course.
- The researchers found specific genetic markers in the major histocompatibility complex (MHC) that correlate with resistance to ADA development, suggesting that these markers play a key role in the effectiveness of biologic therapies.
Treatment of paediatric eczema with narrowband ultraviolet light B therapy.
Photodermatol Photoimmunol Photomed
March 2021
Background: Narrowband ultraviolet B phototherapy (nbUVB) is a well-established, well-tolerated and efficacious treatment for eczema. There is a distinct lack of literature surrounding the therapeutic use of nbUVB in eczema in children and especially in children with higher skin phototypes (III to VI).
Methods: We undertook a retrospective review of children aged 18 years and under with eczema who had undergone nbUVB in our department between 1 January 2011 and 31 December 2017.
Background: X-linked ichthyosis (XLI) is a relatively common, recessive condition caused by mutations in the steroid sulfatase (STS) gene. Common loss-of-function mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris and predispose individuals to atopic eczema.
Objective: To test the hypothesis that co-inheritance of FLG mutations can act as a genetic modifier in XLI.