Exploring the antioxidant potential of leaf extracts mitigating doxorubicin-induced cardiotoxicity in male rats.

Doxorubicin (DOX) is a commonly used drug in chemotherapy for cancer treatment. However, it can cause the threatening side effect of cardiotoxicity. This study investigates whether the hydro-alcoholic leaves of have any protective potential against DOX-induced cardiotoxicity.

Investigation of moxifloxacin loaded chitosan-dextran nanoparticles for topical instillation into eye: In-vitro and ex-vivo evaluation.

Introduction: Management of ocular surface disease by conventional formulation is limited by poor residence of drug at cul-de-sac of eye. To overcome this limitation, prolonged released mucoadhesive chitosan (CS)-dextran sulfate (DS) nanoparticles (NPs) were investigated for the prolonged topical ophthalmic delivery of moxifloxacin (Mox).

Methods: Formulation was optimized by 3-factors (CS, DS, and Mox concentration), 3-levels (-1, 0, +1) Box-Behnken design.