Effect of Pseudomonas aeruginosa cytotoxin on thymidine incorporation by murine splenocytes.

The interaction of highly purified Pseudomonas aeruginosa cytotoxin (PAC) with murine splenocytes was examined. Added at culture initiation, PAC (0.1 to 0.

Distribution analysis of intrauterine pressure in nonpregnant dysmenorrheic women.

Very few attempts to describe, codify , and implement analysis of intrauterine pressure data have occurred in the past. With a growing interest in intrauterine pressure during dysmenorrhea, the need for new ways of evaluating pressure data have become more acute. The availability of fast, compact microcomputers to process these data provides a tool which may make this goal attainable.

A prevalence survey of infections in a combined acute and long-term care hospital.

A prevalence survey of infections among 572 acute and long-term care patients in the Albany Veterans Administration Medical Center was conducted in September 1979. Presence of infection was determined by patient examination and chart review. Urine specimens from 94% of patients were cultured.

In vitro comparison of Pseudomonas aeruginosa isolates with various susceptibilities to aminoglycosides and ten beta-lactam antibiotics.

Susceptibilities of 98 clinical isolates of Pseudomonas aeruginosa, including 33 strains with known mechanisms of amikacin resistance, were tested by the agar dilution method against 10 beta-lactam drugs. Ceftazidime, imipenem, and cefsulodin had the greatest activity, regardless of the aminoglycoside susceptibilities. The strains which were highly resistant to amikacin appeared to be less susceptible to some beta-lactam drugs, especially if their resistance was related to amikacin-inactivating enzymes; statistical significance, however, was observed for aztreonam only.

Absolute bioavailability study in the dog with Visacor, a new cardioselective beta blocking drug with intrinsic sympathomimetic activity.

The cardioselective beta-adrenergic blocking drug Visacor (ICI 141,292) was dosed to six beagle dogs in a randomized cross-over manner. Five formulations were examined i.e.

Intrauterine pressure analysis in nonpregnant dysmenorrheic women.

Past attempts to describe, codify , and implement analysis of intrauterine pressure data have been limited. With a growing interest in intrauterine pressure in dysmenorrhea, the need for multiple, well-defined, reproducible parameters has become greater. The availability of fast, compact microcomputers has provided a tool that makes this goal attainable.

Pharmacokinetics of moxalactam in elderly subjects.

The pharmacokinetics of moxalactam were studied in 19 male volunteers 60 years of age or older with normal liver function tests and a creatinine clearance of greater than or equal to 60 ml/min. Moxalactam was administered in single or multiple intravenous or intramuscular doses. Rapid and complete intramuscular bioavailability was demonstrated in a subgroup of the study population.

Inhibitory and bactericidal activities of amifloxacin, a new quinolone carboxylic acid, compared with those of seven other antimicrobial agents.

The activity of amifloxacin, a new quinolone carboxylic acid compound, against 147 strains of microorganisms was studied and was compared with the activities of cinoxacin, trimethoprim, amikacin, and four beta-lactam antimicrobials. The minimal concentration at which 90% of strains were inhibited by amifloxacin was lowest for Escherichia coli and Klebsiella sp (less than or equal to 0.125 microgram/ml), followed by Proteus sp (less than or equal to 0.

A brief history of intrauterine pressure measurement.

In 1861 the development of obstetrical forceps to measure the degree of uterine expulsive forces gave impetus to investigations of uterine physiology. Although many methods were devised, the intrauterine balloon, used in the first successful attempt to evaluate activity of the gravid uterus in 1872, remained the standard by which other methods were judged. Alternate methods (such as the open catheter technique, hysterosalpingography, electrouterography, and external hysterography) were limited by cumbersome equipment, inaccurate gauges, difficulty in construction, excessive uterine irritation, and restriction of patient movement.

Cyanide prevents the inhibition of platelet aggregation by nitroprusside, hydroxylamine and azide.

Sodium cyanide (CN-) in concentrations of 10 uM or more prevented the inhibition of epinephrine (2.5 uM) and of ADP (4.0 uM) induced primary and secondary aggregation brought about by 10 uM sodium nitroprusside (SNP).

Bacteremia due to Pseudomonas aeruginosa: use of a combined typing system in an eight-year study.

P aeruginosa bacteremia is a nosocomial disease with a high mortality occurring in colonized, debilitated, and leukopenic patients and in those receiving immunosuppressive and antimicrobial agents [2]. Outbreaks of P aeruginosa bacteremia have often been associated with environmental reservoirs [3]. The 190 strains of P aeruginosa described in this study represent single isolates from bacteremic patients during an eight-year period.

Probable strain differences of rats in susceptibilities and cardiopulmonary responses to chronic hypoxia.

Susceptibility to chronic hypoxia in the form of simulated high altitude (HA) have been compared in the adult male Hilltop (H) and Madison (M) Sprague-Dawley rats in terms of their metabolic, hematological and cardiopulmonary responses. Following exposure to either 18 000 or 20 000 ft for 30-40 days, 60-70% of the H rats died or became obviously morbid in contrast to a total absence of morbidity or mortality in the M rats. Autopsy of dead and morbid H rats revealed abdominal and pleural effusions.

Metabolic effects of two triphasic formulations containing ethinyl estradiol and dl-norgestrel.

The metabolic effects of two triphasic oral contraceptive (OC) preparations containing dl-norgestrel (dlN) and ethinyl estradiol (EE) were studied in young women. The marked difference in the two preparations was in the progestogen content, allowing the study of the metabolic effects of high and low progestogen in oral contraception. The results suggest that high progestogen increases serum sodium, potassium, blood urea nitrogen, creatinine, total protein, albumen, and lactic dehydrogenase.

Moxalactam concentrations in human prostatic tissue.

The concentrations of moxalactam in human prostatic tissue, obtained by enucleation or transurethral resection, were measured in 10 patients after the intramuscular administration of two 500-mg doses. The average concentrations of moxalactam in prostatic tissue in the enucleated and transurethral resection specimens were 4.0 micrograms/g and 5.

Heinz body hemolytic anemia in newborns and failure of laboratory studies to implicate a phenolic disinfectant.

Two unrelated, white, female, premature infants in the same hospital nursery contemporaneously exhibited features of an acute, Heinz body hemolytic anemia: decreased levels of hemoglobin and hematocrit, anisocytosis, fragmented cells, hyperbilirubinemia, reticulocytosis, and red cell inclusion bodies. Physical examination and laboratory studies failed to reveal the etiology of this process. Epidemiologic studies indicated a possible association between the reaction and the improper use and inappropriately high concentration of a phenolic disinfectant.

Acute toxicity of some silver salts of sulfonamides in mice and the efficacy of penicillamine in silver.

The silver salt of 2-metanilamido-5-chloropyrimidine (AgMCP) and the sodium, amminosilver and trimethylphosphite-silver salts of 3',5'-dichlorobenzenesulfonanilide (NaDBS, AgNH3DBS and AgP(OCH3)3DBS were synthesized as possible antibiotic of antiparasitic drugs. All the organosilver compounds were extremely water-insoluble. For animal studies these, and other reference compounds, were given as fine suspensions in an Emulphor-safflower oil mixture.