Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): study protocol for a randomised controlled trial.

Background: Non-invasive ventilation (NIV) uses positive pressure to assist people with respiratory muscle weakness or severe respiratory compromise to breathe. Most people use this treatment during sleep when breathing is most susceptible to instability. The benefits of using NIV in motor neurone disease (MND) are well-established.

Return to Play After Arthroscopic Superior Labral Repair: A Systematic Review.

Background: Superior labral tears are common shoulder injuries among athletes, and for athletes undergoing surgical intervention, one of the main priorities is to return to preinjury levels of activity in a timely manner. However, the literature surrounding return to play after superior labral repair presents inconsistent results, with limited studies evaluating the timing of return to play.

Purpose: To systematically review the rate and timing of return to play in athletes after arthroscopic superior labral repair.

Complications of Estimating Hatchery Introgression in the Face of Rapid Divergence: A Case Study in Brook Trout ().

Fish stocking has been utilized for over a century to offset extirpations or declines in abundance of many native species. These historical declines and hatchery contributions have led to uncertainty surrounding whether many contemporary populations are native, introgressed with hatchery sources, or entirely of hatchery origin. Such uncertainty is problematic for the conservation of native biodiversity as it hampers management agencies' ability to prioritize the conservation of indigenous locally adapted populations.

, gen et sp. nov., a small early Permian parareptile with conical teeth from Richards Spur, Oklahoma.

A small, pristinely preserved specimen recently collected from the Dolese Brothers limestone quarry near Richards Spur, Oklahoma provides evidence for the presence of a new early Permian parareptile at this locality. The specimen includes an articulated, nearly complete skull roof, and with the right premaxilla, right quadratojugal, most of the right palate, as well as the right epipterygoid and the sphenethmoid preserved inside. Although similar in many respects to the other contemporary parareptiles , and , it can be distinguished from other acleistorhinids by the presence of a number of autapomorphies related to its dentition.

A Rare Case of Pedunculated, Prolapsed Juvenile Rectal Polyp in a Pediatric Patient.

The prolapse of a pedunculated juvenile rectal polyp is a rare event. It occurs when the polyp protrudes through the anus and appears as a fleshy mass at the anus, leading to an alarming scenario for both the parent and patient and typically prompting a visit to the emergency department (ED). We report a case of a five-year-old male patient who presented to the ED with a prolapsed rectal mass.

A Case of Left-Sided Infective Endocarditis Secondary to Intravenous Drug Use Resulting in Septic Renal Emboli.

Methicillin-sensitive (MSSA) is a gram-positive, coagulase-positive coccus implicated in the pathogenesis of infective endocarditis (IE) due to intravenous drug use (IDU). The tricuspid valve is the most commonly affected valve; however, there is an increased incidence of mitral valve involvement. In this case report, we present a 41-year-old female with no known past medical history but a social history significant for IDU who presented with MSSA bacteremia, sepsis, and IE with vegetations on the mitral valve.

Protocol for Therapeutic Drug Monitoring Within the Clinical Range Using Mid-infrared Spectroscopy.

Therapeutic drug monitoring (TDM), which involves measuring drug levels in patients' body fluids, is an important procedure in clinical practice. However, the analysis technique currently used, i.e.

Remnant Cholecystitis After Subtotal Cholecystectomy: A Case Report.

Remnant cholecystitis is a rare complication following subtotal cholecystectomy (STC), particularly when the reconstituting technique is used, which leaves a portion of the gallbladder behind. This remnant can become inflamed due to recurrent or retained gallstones. We present the case of a 39-year-old female who required a completion cholecystectomy 11 years after her initial STC due to severe recurrent right upper quadrant (RUQ) pain, nausea, and vomiting with an ultrasound that revealed cholelithiasis.

Concomitant Arthroscopic Superior Labral and Rotator Cuff Repair: A Systematic Review.

Background: The aim of this study was to systematically review the literature on concomitant repair of superior labral and rotator cuff tears, in light of the paucity of published clinical evidence.

Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses compliant search of PubMed, Embase, and Cochrane Library databases was performed for clinical studies of patients undergoing combined repairs of the rotator cuff and superior labrum.

Results: Ten studies comprising 241 shoulders were included, with a mean age of 52.

Novel Risk Factors for Postoperative Hematoma Requiring Reoperation Following Anterior Cervical Discectomy and Fusion.

Study Design: Retrospective cohort study.

Objective: To investigate the correlation between comorbid chronic obstructive pulmonary disease (COPD), asthma, tobacco use, and the incidence of postoperative hematoma requiring reoperation after anterior cervical discectomy and fusion (ACDF).

Summary Of Background Data: Prior studies have identified general risk factors such as multilevel fusion and coagulopathy.

The Prevalence of Intraoperative Neuromonitoring in Anterior Cervical Discectomy and Fusion: Trends, Variances, and Value Appraisal.

Study Design: Retrospective cohort study.

Objective: The purpose of this study was to (1) evaluate recent trends in the use of intraoperative neuromonitoring (IONM) for anterior cervical discectomy and fusion (ACDF) in the United States, (2) assess regional variations in the use of IONM, and (3) assess the association between IONM and clinical outcomes.

Summary Of Background Data: IONM is frequently used during anterior cervical procedures to mitigate the risk of neurological injury.

Bayesian merged utilization of GRAPPA and SENSE (BMUGS) for in-plane accelerated reconstruction increases fMRI detection power.

In fMRI, capturing brain activity during a task is dependent on how quickly the k-space arrays for each volume image are obtained. Acquiring the full k-space arrays can take a considerable amount of time. Under-sampling k-space reduces the acquisition time, but results in aliased, or "folded," images after applying the inverse Fourier transform (IFT).

Perforated Jejunal Diverticulum Mimicking Diverticulitis: A Case Report of Acute Abdominal Pain in an Elderly Patient.

Jejunal diverticulosis is a rare form of diverticulosis characterized by acquired pseudodiverticula in the small bowel. Although most cases are asymptomatic, the condition can present diagnostic challenges due to its atypical presentation. Complications such as perforation can lead to acute abdomen, significantly increasing morbidity and mortality.

Contemporary National Trend in Surgical Management of Hemodynamically Unstable Pediatric Blunt Splenic Injury.

Background: Evaluation of response to blood transfusion after blunt splenic injury (BSI) may prevent the need for splenectomy. The aim of this study was to evaluate factors associated with splenectomy in pediatric patients with isolated BSI who presented with hemodynamic instability with a focus on timing of transfusion.

Methods: The 2021 Trauma Quality Improvement Project database was queried for children ≤18 years with BSI who arrived with a shock index>1.

vSPACE: exploring virtual spatial representation of articular chondrocytes at the single-cell level.

Summary: vSPACE is a web-based application presenting a spatial representation of scRNAseq data obtained from human articular cartilage by emulating the concept of spatial transcriptomics technology, but virtually. This virtual 2D plot presentation of human articular cartage cells generates several zonal distribution patterns, for one or multiple genes at a time, revealing patterns that scientists can appreciate as imputed spatial distribution patterns along the zonal axis.

Availability And Implementation: vSPACE is implemented in Python Dash as a web-based toolbox designed for data visualization of zonal gene expression patterns in articular cartilage chondrocytes.

Tape Stripping Method in Dermatological and Pharmacological Research: Evaluating Fresh and Frozen-Thawed Porcine Skin.

Background The stratum corneum (SC) plays a crucial role in protecting the skin and regulating water loss. Tape stripping is a well-established method for studying skin barrier function and evaluating topical treatments. However, the behavior of fresh versus frozen-thawed skin during tape stripping has not been extensively compared.

Tricolor Transgenic Murine Model for Studying Growth Plate Injury.

The cartilage growth plates in the bones of children enable limb lengthening but are weak relative to the bone, making them prone to fracturing when bones are overloaded. Better treatments for severely fractured growth plates are needed because the response to injury is a bony bridge that prematurely fuses the growth plate, leading to stunted and/or crooked limbs. Murine models of growth plate injury are advantageous for mechanistic studies, but are challenging because it is difficult to visualize and precisely injure the small growth plates in young mice.

Competencies for Training Juvenile Services on Justice-Involved Youth with Traumatic Brain Injury.

Research indicates young individuals with traumatic brain injuries (TBI) in juvenile justice settings lack essential support, mainly due to staff members' insufficient knowledge and skills in TBI-related areas stemming from a lack of relevant professional development. This study aimed to improve services for justice-involved youths with TBI in juvenile correction facilities by establishing empirically validated core competencies tailored to their needs. Through a Delphi study involving experts in juvenile services, juvenile corrections, TBI, transition services, and professional development, we identified and refined a set of 44 competencies distributed across six domains: knowledge (12 competencies), screening (6 competencies), eligibility (3 competencies), assessment (4 competencies), intervention (10 competencies), and community reentry (9 competencies).

Brouwer and Hausdorff: On reassessing the foundations crisis.

Epistemological issues associated with Cantorian set theory were at the center of the foundational debates from 1900 onward. Hermann Weyl, as a central actor, saw this as a smoldering crisis that burst into flames after World War I. The historian Herbert Mehrtens argued that this "foundations crisis" was part of a larger conflict that pitted moderns, led by David Hilbert, against various counter-moderns, who opposed the promotion of set theory and trends toward abstract theories.

Characterising Skin Electrical Impedance Using Tape Stripping Methods: A Bioelectrical Study of a Porcine Model.

Background Recent advancements in ultra-low power electronics and wireless devices have facilitated the widespread adoption of wearable technology for fitness and health monitoring, paving the way for personalized medicine. Microneedle-based devices, comprising small epidermal patches that penetrate the skin's stratum corneum to potentially access biomarkers in the extracellular fluid of the viable epidermis, represent a promising innovation in this field. Objectives This project aimed to develop and validate a novel method to evaluate microneedle engagement in the skin in real-time.

Prior Teaching Experience and Barriers to Effective Resident Teaching: A Cross-Sectional Study.

Introduction: Resident physicians play an important role in teaching the next generation of health-care providers, yet limited research has explored factors influencing effective teaching, such as preresidency experiences or barriers within residency. This study examines residents' prior teaching experience, its correlation with teaching attitudes, and identifies potential barriers to sustained teaching engagement.

Methods: This cross-sectional study surveyed residents across multiple specialties at a single academic center.