German S3 guideline on the use of dental ceramic implants.

Purpose: Based on the excellent long-term data, dental implants made of titanium are considered the international implantological standard for replacing missing teeth. However, ceramic implants made of zirconia (ZrO) have experienced a renaissance in the last 15 years due to constant innovations in materials and products, with material properties and soft tissue- and osseointegration behavior comparable to those of titanium. However, one limitation concerning ceramic implants is the lack of reliable long-term data, especially in the case of two-piece implant systems.

Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.

The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischemia provides a pathological setting in which PCoA regulation of ADP/ATP transport would be beneficial, and secondly, whether the chronically elevated lipid content within the diabetic heart could make mitochondria less sensitive to the effects of PCoA. PCoA acutely decreased ADP-stimulated state 3 respiration and increased the apparent K for ADP twofold.

The number of k-mer matches between two DNA sequences as a function of k and applications to estimate phylogenetic distances.

We study the number Nk of length-k word matches between pairs of evolutionarily related DNA sequences, as a function of k. We show that the Jukes-Cantor distance between two genome sequences-i.e.

Titanium and zirconium release from titanium- and zirconia implants in mini pig maxillae and their toxicity in vitro.

Objective: Titanium (Ti)- and Zirconia (ZrO)-implants in mini pig maxillae were compared with respect to Ti/zirconium (Zr) release into the surrounding bone tissues, the resulting short term tissue responses and the potential toxicity.

Methods: Ti/Zr release from Ti- and ZrO-implants in mini pig maxillae was determined with inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). The spatial distribution of Ti and Zr in maxilla tissues near the implant surface was assessed with laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS).

Benchmarking of alignment-free sequence comparison methods.

Background: Alignment-free (AF) sequence comparison is attracting persistent interest driven by data-intensive applications. Hence, many AF procedures have been proposed in recent years, but a lack of a clearly defined benchmarking consensus hampers their performance assessment.

Results: Here, we present a community resource (http://afproject.

9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.

COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane, triggering polymerization and budding. The vesicle uncoats before fusion with a target membrane.

Comparison of calculation methods for estimating annual carbon stock change in German forests under forest management in the German greenhouse gas inventory.

Background: The German greenhouse gas inventory in the land use change sector strongly depends on national forest inventory data. As these data were collected periodically 1987, 2002, 2008 and 2012, the time series on emissions show several "jumps" due to biomass stock change, especially between 2001 and 2002 and between 2007 and 2008 while within the periods the emissions seem to be constant due to the application of periodical average emission factors. This does not reflect inter-annual variability in the time series, which would be assumed as the drivers for the carbon stock changes fluctuate between the years.

Comparison of imaging methods used for dental implant osseous integration assessment.

Two different imaging techniques used to determine bone tissue response to dental implants were compared. Dental implants were implanted into the maxillae of 18 pigs, which were sacrificed after 4, 8 and 12 weeks. Implants with surrounding bone tissue were retrieved for methyl methacrylate histology and contact radiography.

Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission.

Formation of coated vesicles requires two striking manipulations of the lipid bilayer. First, membrane curvature is induced to drive bud formation. Second, a scission reaction at the bud neck releases the vesicle.

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.

Activation of the NF-kappaB pathway in T cells is required for induction of an adaptive immune response. Hematopoietic progenitor kinase (HPK1) is an important proximal mediator of T-cell receptor (TCR)-induced NF-kappaB activation. Knock-down of HPK1 abrogates TCR-induced IKKbeta and NF-kappaB activation, whereas active HPK1 leads to increased IKKbeta activity in T cells.

Osseointegration of zirconia and titanium dental implants: a histological and histomorphometrical study in the maxilla of pigs.

Objectives: The purpose of the present study was to histologically compare the bone tissue responses to surface-modified zirconia and titanium implants.

Methods: Threaded zirconia implants were produced using a new low-pressure injection moulding technique and thereafter surface treated by acid etching. Titanium implants with the exact shape and surface treated by sandblasting and acid etching (SLA) served as controls.

A comparison study of the osseointegration of zirconia and titanium dental implants. A biomechanical evaluation in the maxilla of pigs.

Objectives: The purpose of the present study was to investigate the osseointegration of microstructured zirconia implants in comparison with sandblasted and acid-etched (SLA) titanium implants in a biomechanical study.

Materials: Zirconia implants (4.1 mm in diameter, 10 mm in length) were produced using a new low pressure injection molding technique.

Some factors influencing the survival of patients with less advanced stages of differentiated thyroid cancer.

Two groups of patients with less advanced stages of differentiated thyroid cancer were followed from 2 to more than 25 years: 1. 326 patients with preventive thyroid ablation (PTA) in cases of a tumor without lymphatic and remote metastases; 2. 471 patients with lymph node syndrome.

The rational use of 201Tl scintigraphy in the evaluation of differentiated thyroid cancer.

Fifteen patients with differentiated thyroid cancer were examined following 131I thyroid ablation, of these seven were examined after radio-iodine therapy to disseminated neck cancer. They had no further radio-iodine uptake and were evaluated using a 201Tl scan. In thirteen patients there was a good correlation between the results and the clinical diagnosis, showing no uptake in seven subjects with negative clinical findings, and positive delineation of tumour tissue in the neck region in six patients.

Serum thyroglobulin determinations in patients with differentiated thyroid carcinoma.

Serum thyroglobulin levels were measured in 636 patients with differentiated thyroid carcinoma, in whom altogether 1240 determinations were performed in different phases of disease and treatment. A modified sensitive radioimmunoassay was employed using an own high-specific thyroglobulin antibody. The results showed that both the majority of patients with functioning metastases accumulating radioiodine and with non-functioning metastases which could not be detected by scanning had higher serum TG levels, compared with a group of healthy subjects.