Substrate-bound factors stimulate engorgement of growth cone lamellipodia during neurite elongation.

The surfaces on which neurons grow greatly affect neurite elongation, but it is unclear how substrates influence the events within the growth cone that bring about elongation. Neurite elongation by Aplysia californica neurons in culture occurs through a series of transformations of the structures of the growth cone (Goldberg and Burmeister, J. Cell Biol.

[Arteriosclerosis obliterans. Treatment with angiotensin-converting enzyme inhibitors].

We compare the effects of two of the main angiotensin convertase enzyme inhibitors, captopril and enalapril, aiming to evaluate their effects in the arterial circulation performance, micro-circulation, and changes in regional blood flow, assuming their property of lowering the angiotensin II blood levels, a very strong peripheral vasoconstrictor. We studied 22 patients: all of them with hypertension and/or skin ulcerations, dropping out those who had venous. They were evaluated periodically, clinically and with photoelectric plethysmography of lower extremities.

Scleromyxedema and severe myositis.

A case of scleromyxedema with associated rhabdomyolysis is reported. This appears to be a well-documented, although rare complication of scleromyxedema. This case is unique in that mucin was demonstrated in the muscle as well as the skin, and spontaneous resolution of the rhabdomyolysis occurred with the implementation of IV fluids and bed rest.

Spatial segregation of the regulated and constitutive secretory pathways.

Recent experiments using DNA transfection have shown that secretory proteins in AtT-20 cells are sorted into two biochemically distinct secretory pathways. These two pathways differ in the temporal regulation of exocytosis. Proteins secreted by the regulated pathway are stored in dense-core granules until release is stimulated by secretagogues.

In vitro effects of somatostatin and urotensin II on prolactin and growth hormone secretion in tilapia, Oreochromis mossambicus.

The control of release of two recently characterized forms of prolactin (PRL) of molecular mass 24 and 20 kDa was investigated. The rostral pars distalis of male tilapia was incubated singly in a hypotonic modified Krebs-Ringer bicarbonate medium in order to stimulate PRL release; for comparison, the proximal pars distalis containing growth hormone (GH) cells was incubated in isotonic medium with or without 1 microgram/ml cortisol to stimulate GH release. The release of both PRLs and GH into the medium was measured by sodium dodecyl sulfate (SDS)--polyacrylamide gel electrophoresis followed by densitometry.

Structured methods for working with task groups.

Although both administrators and line workers are called upon to lead and to staff a variety of different task groups in social service organizations, little attention has been given to learning systematically methods of task group leadership. The author reviews four methods for conducting task groups, including problem solving, brainstorming , nominal group technique, and social judgment analysis. The strengths and weaknesses of each method are analyzed, and some suggestions are made for selecting a method that addresses the needs and purposes of particular groups.

Perspectives on dismissal as a management prerogative in social service organizations.

The process and practice of employee dismissal is an important and nagging task in personnel management in the human services. The employee has come to view one's status, following a probationary period, as permanent. Antidiscrimination laws, unionization, grievance rights, the cost of replacing and retraining, etc.