[Retinal changes in cystinosis].

Cystinosis is a rare autosomal recessive hereditary enzymopathy which leads to accumulation of cystine in the reticuloendothelial system of the liver, spleen, lymph nodes, etc. The pathognomonic alterations of the cornea are characterized by multiple crystalline deposits, chiefly in the limbus area and in the anterior corneal stroma. The retinal changes are seldom described in the literature; they are characterized by a fine-grained pigment shift which intensifies from the macula toward the preequator area and which gives the fundus a 'salt and pepper' appearance.

Quantitative measurement of retinal blood flow in human beings by application of digital image-processing methods to television fluorescein angiograms.

A method is presented that allows the quantitative determination of the blood flow in retinal arteries in human beings. Television fluorescein angiograms are used as input. This method does not need any gauge procedures since all the necessary information is taken from the image itself.

[Clinical and immunological studies of Behçet's disease].

8 patients with clinically diagnosed Behçet disease were immunologically investigated. Uveitis was present in 7 of these patients. Although uveitis is a rare presentation of Behçet's disease, it tends to be bilateral when it does occur and to involve both the anterior and posterior segments repeatedly.

Hyperparathyroidism and anemia in chronic renal failure.

The clinical course of an adolescent on chronic hemodialysis with severe hyperparathyroidism, osteodystrophy and profound anemia is described. After 1,25,dihydroxycholecalciferol was instituted for therapy, bone disease improved as evidenced by radiographic findings. Transfusion requirements diminished and bone marrow fibrosis on serial biopsies decreased significantly.

Osteonecrosis of the femoral head and condyle in the post transplantation courses of children and adolescents.

The clinical courses of 29 children and adolescents who received their first renal allografts at the University of Florida from 1973 to 1979 were reviewed for the development of osteonecrosis. A minimum follow-up period of 24 months with adequate allograft function was required for inclusion in the study. The incidence of post transplantation osteonecrosis was 21%.

Treatment of urinary tract infections with a combination of amoxicillin and clavulanic acid.

A 10-day course of amoxicillin (250 mg)-potassium clavulanate (125 mg) was administered three times daily to 116 female college students with urinary tract infections. All of the bacterial isolates from these patients were susceptible to amoxicillin-potassium clavulanate in vitro; only 81.0% were susceptible to amoxicillin alone.

[Absence of the anterior chamber following cataract extraction ].

A non-existent or extremely flat anterior chamber following cataract extraction is now very rare due to the fact that waterproof wound closure has become standard practice. Among 1,051 cataract operations carried out in our clinic during the past three years this complication was observed only 13 times, i.e.

[Synergistic activity between ticarcillin, azlocillin, cefsulodin, ceftazidime and tobramycin or amikacin against Pseudomonas aeruginosa (author's transl)].

Activity of azlocillin, cefsulodin, ceftazidime, ticarcillin in combination with amikacin or tobramycin was investigated against 17 Pseudomonas aeruginosa isolates. Synergistic activity was evaluated by the microtiter checkerboard technique. The bactericidal effect of the antibiotic combination was determined by subculturing onto agar and into broth.

Trimethoprim once daily vs. nitrofurantoin in treatment of acute urinary tract infections in young women, with special reference to periurethral, vaginal, and fecal flora.

College women with acute urinary tract infections were assigned randomly to three groups: 110 received trimethoprim (TMP), 300 mg once a day for seven days (group 1); 104 received TMP, 200 mg once a day for 10 days (group 2); and 108 received nitrofurantoin, 100 mg four times a day for 10 days (group 3). All primary urinary pathogens were sensitive to TMP, and 98.8% were sensitive to nitrofurantoin.

Treatment of acute uncomplicated urinary tract infections by cephalexin, with special reference to the antibody-coated bacteria.

In 68 college-age females with acute uncomplicated urinary tract infections (UTI), ACB testing revealed that 36.8% of the infections were localized in the kidney and 63.2% in the urinary bladder.

Depression by Pseudomonas aeruginosa of two T-cell-mediated responses, anti-Listeria immunity and delayed-type hypersensitivity to sheep erythrocytes.

Pseudomonas aeruginosa was studied for its effects on T-cell-mediated responses in mice, as exemplified by anti-Listeria immunity and delayed-type hypersensitivity to sheep erythrocytes. Immunity to Listeria monocytogenes was measured by quantitation of bacteria in spleens and mortality; delayed hypersensitivity to sheep erythrocytes was tested by the footpad reaction. Three different preparations of P.

Compensatory renal growth and function in postnephrectomized patients with Wilms tumor.

The objective of this study was to determine whether or not renal growth and function were adversely affected in the remaining kidneys of patients who had undergone nephrectomy for Wilms tumor. These patients received chemotherapy and some radiotherapy (tumoricidal agents which might affect the remaining kidney). Renal growth was compared between the treatment groups and normal renal growth.

[Fundus albipunctatus in primary oxalosis (author's transl)].

Primary oxalosis causes a flecked retina showing multiple small luminous spots at the posterior pole which can be seen by fluorescein angiography. In a young female patient who was observed for 4 years we did not find any deterioration. In 2 patients with secondary oxalosis, there was no evidence of fundus alterations.

The use of rare-earth magnet couplers in cochlear implants.

The cochlear implant is an electronic auditory prosthesis gaining widespread acceptance as a means of restoring partial hearing to the totally deaf. A number of engineering and biological hurdles remain toward the improvement of existing implantable systems and development of multichannel systems. One hurdle concerns reliable transcutaneous coupling of the external electric signal to the implanted device.

Hypertension in a pediatric and adolescent population following kidney transplantation.

The post-renal transplant courses of 53 children and adolescents were evaluated for the prevalence and the etiology of hypertension. The blood pressures were averaged over specific time periods following transplantation and converted to percentile ranks according to standards for age. The number of antihypertensives employed to control blood pressure was assessed.

Liver dysfunction in children and adolescents during hemodialysis and after renal transplantation.

Liver dysfunction is common in patients on hemodialysis or during the posttransplant period. Twelve children in the End-Stage Renal Disease Program at the University of Florida ranging in age from 4 to 18 years, developed persistent, elevated liver enzymes (SGOT or SGPT greater than 100 IU/liter) during hemodialysis in preparation for renal transplantation. Eleven of 12 developed enzyme elevations within six weeks of the initiation of hemodialysis.

Treatment of uncomplicated urinary tract infections with trimethoprim versus sulfisoxazole, with special reference to antibody-coated bacteria and fecal flora.

A total of 331 college-age women with urinary tract infections were studied. These women were assigned randomly to the following groups: 50 patients treated with 400 mg of trimethoprim (TMP) per day for 14 days (designated the TMP400/14d group); 50 treated with 2.0 g of sulfisoxazole (SZ) per day for 14 days (SZ/14d group); 120 treated with 200 mg of TMP per day for 10 days (TMP200/10d group); and 111 treated with 2.

Comparative efficacy and safety of nalidixic acid versus trimethoprim/sulfamethoxazole in treatment of acute urinary tract infections in college-age women.

One hundred and thirty-five college-age women with acute urinary tract infections caused by gram-negative Enterobacteriaceae were treated by random allocation with either nalidixic acid (NA), 1 g every 6 h for 7 days, or trimethoprim/sulfamethoxazole (TMP/SMZ), 160/800 mg every 12 h for 10 days. The clinical and bacteriological cure rates were 98.0% in each group on the last day of therapy.

The effect of pentoxifylline on circulatory disturbances of the retina and optic nerve. A report of ten years clinical experience.

Report on 178 cases of vascular circulatory disturbances of the retina and the optic nerve treated with pentoxifylline. Fifty three patients had a vascular occlusion of the central retinal artery, 53 of a branch of a retinal artery, 72 of the artery of the optic nerve. The ophthalmoscopic, fluoroangiographic, therapeutic, and prognostic problems are discussed.