Inner engineering is associated with perceived improvements in relationship quality, interpersonal connections, and interpersonal compassion.

Objectives: Interpersonal relationships are a cornerstone of wellbeing. Mindfulness-based practices have been shown to improve relationship quality and reduce perceived stress. Inner Engineering (IE) is a transformative program that includes meditative and yogic practices associated with improvements in mindfulness and wellbeing.

Spatiotemporal variation in population dynamics of a narrow endemic, Ranunculus austro-oreganus.

Premise: Understanding how population dynamics vary in space and time is critical for understanding the basic life history and conservation needs of a species, especially for narrow endemic species whose populations are often in similar environments and therefore at increased risk of extinction under climate change. Here, we investigated the spatial and temporal variation in population dynamics of Ranunculus austro-oreganus, a perennial buttercup endemic to fragmented prairie habitat in one county in southern Oregon.

Methods: We performed demographic surveys of three populations of R.

seroprevalence in dogs, cats, and horses in Tennessee, USA.

We estimated the seroprevalence in dogs, cats, and horses from Tennessee, USA, using the microscopic agglutination test (MAT) against 12 serovars. We observed seropositivity in 110 of 374 (29.4%) dogs, 21 of 170 (12.

Pop-out effects revisited: Within-array category pop-out and novel pop-out effects with picture stimuli.

Pop-out effects occur when a novel or different stimulus is presented in the context of an array of otherwise familiar or similar stimuli. The effect has been studied using words extensively, but little evidence exists for humans relating to nonverbal stimuli. Although the finding has implications for understanding features of stimuli that capture attention, contradictory findings exist, and previous paradigms have limited applicability to real world situations.

3-hour genome sequencing and targeted analysis to rapidly assess genetic risk.

Purpose: Rapid genetic testing in the critical care setting may guide diagnostic evaluation, direct therapies, and help families and care providers make informed decisions about goals of care. We tested whether a simplified DNA extraction and library preparation process would enable us to perform ultra-rapid assessment of genetic risk for a Mendelian condition, based on information from an affected sibling, using long-read genome sequencing and targeted analysis.

Methods: Following extraction of DNA from cord blood and rapid library preparation, genome sequencing was performed on an Oxford Nanopore PromethION.

Enhancing Telehealth Accessibility for Older Adults in Underserved Areas: A 4M Framework Approach.

Telehealth has emerged as a vital alternative to traditional healthcare delivery, particularly for rural and underserved populations. While efforts to enhance telehealth accessibility have primarily focused on technological solutions, the effectiveness of its telehealth and the role of physician training in bridging racial and ethnic disparities in telehealth usage remains underexplored. This study evaluates the impact of a trained-physician-delivered, age-friendly telehealth model on healthcare accessibility and outcomes.

Resilient water infrastructure partnerships in institutionally complex systems face challenging supply and financial risk tradeoffs.

As regions around the world invest billions in new infrastructure to overcome increasing water scarcity, better guidance is needed to facilitate cooperative planning and investment in institutionally complex and interconnected water supply systems. This work combines detailed water resource system ensemble modeling with multiobjective intelligent search to explore infrastructure investment partnership design in the context of ongoing canal rehabilitation and groundwater banking in California. Here we demonstrate that severe tradeoffs can emerge between conflicting goals related to water supply deliveries, partnership size, and the underlying financial risks associated with cooperative infrastructure investments.

Human causality detection and judgment with unsignaled and signaled delayed outcomes.

Four experiments examined human ratings of causal effectiveness, and ability to detect causal relationships, in a nonverbal paradigm. Participants responded on a concurrent random interval, extinction schedule. In the presence of one stimulus, responses produced an outcome (triangle flash); in the presence of the other stimulus, they did not.

Research to Confront Climate Change Complexity: Intersectionality, Integration, and Innovative Governance.

Climate impacts increasingly unfold in interlinked systems of people, nature, and infrastructure. The cascading consequences are revealing sometimes surprising connections across sectors and regions, and prospects for climate responses also depend on complex, difficult-to-understand interactions. In this commentary, we build on the innovations of the United States Fifth National Climate Assessment to suggest a framework for understanding and responding to complex climate challenges.

Moral Distress as Moral Heuristic Missing the Mark.

I propose that moral distress may function as a moral heuristic, and one that misses its mark in signifying a fundamental source for nurses' moral suffering. Epistemic injustice is an insidious workplace wrongdoing that is glossed over or avoided in explicit explanations for nurse moral suffering and is substituted by an emphasis on the nurse's own wrongdoing. I discuss reasons and evidence for considering moral distress as a that obfuscates the role of epistemic injustice as a fundamental constraint on nurses' moral reasoning underlying moral suffering.

Exploring Psychedelics for Alleviating Existential and Spiritual Suffering in People With Serious Illnesses: Links to the Theory of Self-Transcendence.

The fields of palliative and holistic Nursing are dedicated to providing comprehensive care for the person, emphasizing special attention to the existential and spiritual aspects of care. Psychedelic-assisted therapy has emerged as a promising approach for symptom management in individuals with serious illnesses, particularly those of existential and spiritual origin. People who undergo challenging experiences, as is the case with serious illnesses, often undergo an identity crisis and question the purpose of their lives.

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission.

Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in monozygotic twins, about half of twin pairs are discordant for schizophrenia.

Patient Perceptions of Surveillance of Small Abdominal Aortic Aneurysms in the Over 85s.

Background: Recently instigated local practice for patients with small abdominal aortic aneurysms (AAAs) involves contacting all patients, aged ≥85 years, to discuss with them the advantages and disadvantages of removal from surveillance. However, reasons why patients opt to remain on, or come off, surveillance, are currently unknown. The present study's objective is to explore patient perception of surveillance decision-making.

Prevalence and drug use correlates of inadvertent fentanyl exposure among individuals misusing drugs in seven U.S. states.

Fentanyl has emerged as the leading cause of fatal drug overdoses in the U.S. Individuals misusing drugs may not always be aware of exposure to fentanyl.

Direct-To-Definitive Urine and Oral Fluid Test Results for Unscreened and Rarely Screened Drugs in Individuals Applying for Methadone Treatment in 7 U.S. States.

The standard protocol in addiction treatment/pain management is to conduct immunoassay screens for major drugs subject to misuse, followed by confirmatory testing of positive results. However, this may miss unscreened or rarely screened drugs that could pose risks, especially to polydrug users. We sought to determine the prevalences of unscreened/rarely screened drugs in a sample of individuals misusing drugs in 7 U.

A CRISPRi-based genetic resource to study essential genes.

is an important clinical pathogen that causes a high number of antibiotic-resistant infections. The study of biology, and particularly of the function of essential proteins, is of particular importance to develop new approaches to combat this pathogen. We have optimized a clustered regularly interspaced short palindromic repeat interference (CRISPRi) system that allows efficient targeting of essential genes.

A New Nursing Aesthetic.

Conceptions of the art and aesthetics of nursing traditionally focus on the nurse and nursing practice. My purpose here is to propose a shift in thinking from this traditional focus that dominates the "art of nursing" literature, to consider a new nursing aesthetic that focuses on human beings proper: I present a framework based on everyday aesthetics, feminist aesthetics, and Deweyan perspectives, along with attention to the nursing disciplinary perspective of health and well-being. I conclude with a look ahead to philosophical questions and scientific issues regarding theorizing and scientific inquiry about the aesthetic to advance nursing knowledge.

Effect of instructions on the microstructure of human schedule performance.

Three experiments examined the effect of instructions on human free-operant performance on random ratio (RR) and random interval (RI) schedules. Both rates of responding, and the microstructure of behavior, were explored to determine whether bout-initiation and within-bout responding may be controlled by different processes. The results demonstrated that responding in acquisition (Experiments 1 and 2) and extinction (Experiment 3) was impacted in line with given instructions.