A comprehensive analysis of BiOBr has been carried out using first-principles density-functional theory (DFT) to explore the electronic structure, energy band structure, and essential properties related to its photocatalytic performance. DFT calculations reveal that BiOBr, BiOBr, BiOBr, BiOBr, BiOBr, and BiOBr have different indirect bandgap values of 2.46 eV, 2.
View Article and Find Full Text PDFMacrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg entry through distinct plasma membrane channels is critical to macrophage plasticity. Naïve macrophages displayed a previously unidentified Mg dependent current, and TRPM7-like activity, which modulates its survival.
View Article and Find Full Text PDFHeliyon
January 2025
The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide contributing to a large number of mortalities. Though potentially curable they are mostly fatal due to late diagnosis and lack of accurate diagnostic markers. microRNA, micromanagers of gene expression have been associated to have distinct roles as oncogenes or tumour suppressors in several cancers including GI cancers.
View Article and Find Full Text PDFPlant-derived phytochemicals are crucial in fighting bacterial infections and in cancer therapy. This study investigates the phytochemical composition of the ethanolic extract obtained from () seeds and assesses its antimicrobial, anticancer, and antioxidant activities. GC-MS analysis found 30 phytochemicals in seeds, including 5 bioactive compounds that have been shown to have antioxidant, antimicrobial, and cytotoxicity properties, through in silico evaluation.
View Article and Find Full Text PDFDoped semiconductors are often used to improve photocatalytic efficiency and address the challenges of easy recombination of electron-hole pairs and poor photoluminescence. However, the reproducibility and complexity of experimental studies result in time-consuming and less cost-effective studies, and it is difficult to gain insights into the intrinsic properties of doped photocatalysts to control their performance. Introducing a machine learning approach, we constructed a photocatalytic model of transition-metal- and rare earth metal-ion-doped γ-BiMoO.
View Article and Find Full Text PDFStudy Design: Prospective analysis of retrospective data.
Objectives: To analyse the clinical and radiological outcomes of thoracic and thoracolumbar TB kyphosis by a posterior-only approach using kyphosis classification.
Methods: Patients with thoracic and thoracolumbar spinal TB who underwent posterior-only surgical correction for kyphotic deformity >30° were categorized into Group: A (Active TB) and Group B (Healed TB).
Study Design: Observational comparative study.
Objective: To study the role of magnetic resonance spectroscopy (MRS) and T2 relaxometry (T2r) as imaging biomarkers for identifying early lumbar disc degeneration.
Methods: We evaluated 236 discs in normal volunteers and 215 discs in low back pain (LBP) patients by MRS and T2r to document the molecular spectra of various metabolites as well as disc hydration and collagen content, respectively.
Ann Pediatr Cardiol
November 2024
Association of Ebstein's anomaly of tricuspid valve (TV) with tetralogy of Fallot (TOF) is extremely rare. Their coexistence is unique as they modify each other's physiology. We report a case of a girl child having this rare combination along with Diamond-Blackfan syndrome awaiting a bone marrow transplant.
View Article and Find Full Text PDFAbout one-third of individuals with diabetes develop diabetic retinopathy (DR), with one-tenth experiencing vision-threatening conditions such as diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR). Current treatments only show recovery in 50% of cases, and the disease often remains asymptomatic. Therefore, novel early detection methods and new biomarkers are crucial.
View Article and Find Full Text PDFPurpose: The endocannabinoid system (ECS) has been well-established to play a crucial role in the regulation of several physiological processes as well as many inflammatory disease conditions. However, its role in intervertebral disc degeneration has been least explored. We aim to investigate the immunomodulatory role of endocannabinoids in regulating IVD health.
View Article and Find Full Text PDFBackground Dendritic cells (DCs) are a group of cells that mainly function as antigen-presenting cells in the human body. Proper knowledge and understanding of such cells in the human cervix would be beneficial for understanding the role of CD83+ cells in benign and malignant lesions of the cervix. Materials and methods This retrospective study was performed on cervical specimens.
View Article and Find Full Text PDFOur study focuses on sustainable dye wastewater management through catalysis, scrutinized by surface-enhanced Raman spectroscopy (SERS) using an ecofriendly magnetic nanocomposite (FeO/SiO/Ag (FSA)). To our knowledge, the use of green synthesis for fabricating nanocomposites from a single source, namely Nerium oleander leaves, has not been extensively explored. This poses a distinctive and challenging approach, differentiating it from conventional chemical methods.
View Article and Find Full Text PDFIntroduction The most vital joint for locomotion is the knee joint, which is a condylar, modified hinge joint. Osteoarthritis is a degenerative disease commonly affecting the knee joint, which can be successfully treated by joint replacement surgeries wherein the condyles of the affected knee joints are replaced based on the measurement of the condyles for which the accurate morphometric values of the tibia and femur play an important role thereby decreasing the complications post-surgery and improving the mobility and quality of life of patients. Aim The present study aims to evaluate the morphometric data of femoral condyles and compare the morphometric data of the left and right femurs using the direct method.
View Article and Find Full Text PDFThe abdominal aorta extends from the T12 vertebra and terminates at the L4 vertebra. It gives off anterior, lateral, and posterior branches that supply the abdominal viscera and vertebrae at this level, eventually dividing into the common iliac arteries. Dissection of the abdominal aorta and its branches from a female cadaver revealed several variations: the right inferior phrenic artery arose from the celiac trunk, the left middle suprarenal artery originated at the L1 vertebra, while the right middle suprarenal artery arose at the L2 vertebra, and the left and right renal arteries emerged from the L2 and L1 vertebrae, respectively.
View Article and Find Full Text PDFHigh levels of antibiotic accumulation and the difficulty of degradation can have serious consequences for the environment and, therefore, require urgent attention. To solve this problem, a synergistic Er and Cd ion-codoped BiOBr photocatalyst was proposed. The degradation rate of sulfamethoxazole (SMX) by Er/Cd-BiOBr was eight times higher than that of pure BiOBr, exceeding that of single Er-doped or Cd-doped BiOBr, which was attributed to the ability of Er/Cd-BiOBr to generate a variety of free radicals.
View Article and Find Full Text PDFPurpose: Recently, there has been significant focus on extracellular matrix proteolysis due to its importance in the pathological progression of intervertebral disc degeneration (IVDD). The present study investigates the circulating levels of extracellular matrix proteins in the plasma of IVDD and determines their potential relevance as biomarkers in disc degeneration.
Methods: Global proteomic analysis was performed in the plasma samples of 10 healthy volunteers (HV) and 10 diseased subjects (DS) after depletion of highly abundant proteins such as albumin and IgG.
The formation, stabilization, and elimination of synapses are tightly regulated during neural development and into adulthood. Pumilio RNA-binding proteins regulate the translation and localization of many synaptic mRNAs and are developmentally downregulated in the brain. We found that simultaneous downregulation of Pumilio 1 and 2 increases both excitatory and inhibitory synapse density in primary hippocampal neurons and promotes synapse maturation.
View Article and Find Full Text PDFBackground Information: Microvilli are finger-like, straight, and stable cellular protrusions that are filled with F-actin and present a stereotypical length. They are present in a broad range of cell types across the animal tree of life and mediate several fundamental functions, including nutrient absorption, photosensation, and mechanosensation. Therefore, understanding the origin and evolution of microvilli is key to reconstructing the evolution of animal cellular form and function.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) is difficult to treat breast cancer subtype due to lack or insignificant expressions of targetable estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). Therefore, finding a targetable protein or signaling pathway in TNBC would impact patient care. Here, we report that a member of the Mixed Lineage Kinase (MLK) family, MLK3, is an effector of G-protein-coupled protease-activated receptors 1 (PAR1) and targeting MLK3 by a small-molecule inhibitor prevented PAR1-mediated TNBC tumorigenesis.
View Article and Find Full Text PDFStudy Design: Review article.
Objectives: A review of literature on the epidemiology, natural course, pathobiology and clinical implications of vertebral endplate changes.
Methods: A literature search was performed using the Cochrane Database of Systematic Reviews, EMBASE, and PubMed.
A series of Dy ions doped NaBaBO phosphors with different dopant concentration was synthesized by solid state reaction. The phase purity was checked by X-ray diffraction analysis and the functional groups present in as prepared phosphors was investigated with the help of FTIR spectral analysis. Under 386 nm excitation, the photoluminescence spectra exhibit three emission bands around 482 nm, 574 nm and 664 nm due to F→H (J = 15, 13, 11) transions respectively.
View Article and Find Full Text PDFPolymer microparticles are often used to encapsulate drugs for sustained drug-release treatments. One of the ways they are manufactured is by using a solvent extraction process, in which the polymer solution is emulsified into an aqueous bulk phase using a surfactant as a stabilizing agent, followed by the removal of the solvent. The radius of a polymer drop decreases as a function of time until the polymer reaches the gelling point, after which it is separated and dried.
View Article and Find Full Text PDFBackground: Intraoperative neuromonitoring (IONM) alert is one of the worrying events of kyphosis corrective surgery, which can result in a postoperative neurological deficit. To our knowledge, there is no risk prediction score to predict such events in patients undergoing kyphosis surgery.
Purpose: To develop a new preoperative MRI-based cord morphology classification (CMC) and risk prediction score for predicting IONM alerts in patients with kyphotic deformity.