Publications by authors named "R-M Szeimies"
Article Synopsis
- Recent studies show that traditional clinical classifications for actinic keratosis (AK) may not accurately reflect treatment effectiveness, and the relationship between keratinocyte atypia and treatment outcomes is not well explored.
- The study evaluated how the degree of keratinocyte atypia influences the efficacy of photodynamic therapy (PDT) using 10% aminolevulinic acid (ALA) gel in treating AK lesions.
- The findings indicate that PDT with red light is effective across different levels of keratinocyte atypia, with higher clearance rates observed when using narrow-spectrum lamps compared to broad-spectrum ones.
Photodynamic therapy in dermatology: established and new indications.
J Dtsch Dermatol Ges
December 2024
Photodynamic therapy (PDT) is internationally established as an approved treatment option for in situ forms of keratinocytic skin cancer (actinic keratoses, Bowen's disease, basal cell carcinoma). For these indications, there are standardized treatment protocols using narrow-spectrum light sources or (artificial) daylight, the use of which is associated with successful healing, a low rate of lesion recurrence, and a very good cosmetic result. Daylight PDT is superior to conventional PDT in terms of significantly less pain and associated higher patient acceptance.
View Article and Find Full Text PDFEffective treatment of actinic keratosis on the hands with red light photodynamic therapy using BF-200 ALA.
Photodiagnosis Photodyn Ther
October 2024
Background: Acral actinic keratosis (AK) lesions are considered difficult to treat, and published data for photodynamic therapy (PDT) on these lesions is limited. Thus, we evaluated sustained efficacy, safety, and satisfaction after PDT for AK on the hands.
Methods: We analysed subgroup data for treatment on the hands from a randomised, double-blind, intra-individual phase III study.
Background: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.
Methods/design: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months.