Publications by authors named "R-D Coletta"
The major cause of bacterial resistance to β-lactams is the production of hydrolytic β-lactamase enzymes. Nowadays, the combination of β-lactam antibiotics with β-lactamase inhibitors (BLIs) is the main strategy for overcoming such issues. Nevertheless, particularly challenging β-lactamases, such as OXA-48, pose the need for novel and effective treatments.
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- mPGES-1 is a key enzyme that converts PGH₂ to PGE₂ and is linked to inflammation-related diseases, making it a target for anti-inflammatory drugs.
- Although several compounds have been developed to target human mPGES-1, they lack specificity and show little activity against mouse mPGES-1, complicating preclinical studies.
- This research aims to identify the binding modes of murine mPGES-1 through modeling and mutagenesis, comparing it to human mPGES-1 to aid in the design of more effective inhibitors for both species.
The reaction of human hemoglobin with carbon monoxide has been investigated near the equilibrium isosbestic wavelength (i.e. 426 nm).
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