Publications by authors named "R-A Lavergne"
Article Synopsis
- Pneumocystis jirovecii pneumonia (PcP) has high mortality rates, and the effect of immunocompromising diseases on its severity and outcomes hasn't been thoroughly studied.
- This retrospective study analyzed 481 patients diagnosed with PcP between 2011 and 2021, revealing that those with immune-mediated inflammatory diseases (IMIDs) or solid tumors had worse survival rates at 90 days.
- Key factors increasing 90-day mortality included having solid tumors, long-term corticosteroid use, sputum cysts, and higher SOFA scores, with prior corticosteroid therapy, particularly daily prednisone doses ≥10mg, being most impactful among HIV-negative patients.
Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to fungicide-driven mutations in the cyp51A gene and its promoter region. We investigated the presence of environmental azole-resistant A.
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