Publications by authors named "R van der Meel"
Background: Ewing sarcoma of the head and neck (ES-HN) is a rare subsite of ES, where therapeutic outcomes need to be explored further.
Methods: This retrospective study includes ES-HN patients registered at our center between 2003 and 2019. Demographic details and treatment outcomes were recorded from the hospital database.
We report a rare case of late-onset vitamin K deficiency bleeding in a 3-month-old boy who presented with orbital compartment syndrome due to massive bleed in the right orbit. The coagulation profile was highly abnormal. The patient was treated with vitamin K injections, following which the coagulation profile normalized.
View Article and Find Full Text PDFHigh pigmentation and the abundance of M2 macrophages have been identified as negative predictors in uveal melanoma (UM). Risk factors associated with UM that are prevalent in high-risk White populations are still present, although less common, in relatively low-risk Asian populations. Research indicates that proangiogenic M2 macrophages and monosomy 3 play significant roles in UM progression.
View Article and Find Full Text PDFTargeted orbital intervention in the management of sino-orbital mucormycosis cases.
Indian J Ophthalmol
October 2024
Article Synopsis
- A significant increase in cases of sino-orbital mucormycosis (SOM) was observed during the COVID-19 pandemic, leading to a need for effective treatment options beyond traditional orbital exenteration.
- A study comparing the use of intraorbital injections with Amphotericin B (IOAB) showed that most patients (88.5%) had stable orbital disease after treatment, with minimal deterioration in visual acuity.
- The findings suggest that IOAB may improve outcomes for patients with mild to moderate SOM, as only a small percentage experienced relapse, highlighting its potential as a globe-conserving therapy.
Purpose: The coronavirus disease 2019 (COVID-19) pandemic led to overall interrupted medical care, resulting in disease progression and morbidity. The study aimed to evaluate clinicopathological presentations and severity of eyelid malignancy during the COVID era, comparing the results with patients presented during pre-COVID era and evaluating the reasons for delayed presentation in patients with advanced eyelid malignancy in the COVID-era.
Methods: This was a comparative, ambispective observational study.