Publications by authors named "R van Mechelen"
Article Synopsis
- The COVID-19 pandemic has been labeled the deadliest disease event, with about 50,000 deaths in the Netherlands from 2020-2022, compared to 32,000 from the Spanish flu between 1918-1920.
- However, the crude mortality rates indicate that Spanish flu was actually deadlier, with 486 deaths per 100,000 compared to 287 for COVID-19.
- When adjusting for population differences, the study shows that the Spanish flu likely had higher age-standardized mortality rates than COVID-19, suggesting it was more lethal overall.
The key risk factor for glaucoma is increased intraocular pressure (IOP). Glaucoma drainage devices implanted in the eye can reduce IOP and thus stop disease progression. However, most devices currently used in clinical practice are passive and do not allow for postsurgical IOP control, which may result in serious complications such as hypotony (i.
View Article and Find Full Text PDFFibrosis of the filtering bleb is one of the main causes of failure after bleb-forming glaucoma surgery. Intraoperative application of mitomycin C (MMC) is the current gold standard to reduce the fibrotic response. However, MMC is cytotoxic and one-time application is often insufficient.
View Article and Find Full Text PDFLowering intraocular pressure (IOP) by placement of a glaucoma shunt is an effective treatment for glaucoma. However, fibrosis of the outflow site can hamper surgical outcome. In this study, the antifibrotic effect of adding an endplate (with or without microstructured surface topographies) to a microshunt made of poly(styrene-block-isobutylene-block-styrene) is investigated.
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