Publications by authors named "R van Luijk"
Whole-heart 4D-flow MRI is a valuable tool for advanced visualization and quantification of blood flow in cardiovascular imaging. Despite advantages over 2D-phase-contrast flow, clinical implementation remains only partially exploited due to many hurdles in all steps, from image acquisition, reconstruction, postprocessing and analysis, clinical embedment, reporting, legislation, and regulation to data storage. The intent of this manuscript was 1) to evaluate the extent of clinical implementation of whole-heart 4D-flow MRI, 2) to identify hurdles hampering clinical implementation, and 3) to reach consensus on requirements for clinical implementation of whole-heart 4D-flow MRI.
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- The study examines how genetic factors influence DNA methylation (DNAm), which is crucial for understanding gene regulation and diseases, using data from 32,851 participants.
- Researchers identified genetic variants linked to DNAm at over 420,000 sites and created a database of more than 270,000 independent mQTLs, highlighting the complexity and polygenic nature of DNAm levels.
- The findings suggest that while some shared genetic variants are linked to both DNAm and complex diseases, only a few cases indicate a direct causal relationship, revealing a complicated connection between genetics and phenotypes.
Background: DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identify 818 genes that affect DNA methylation patterns in blood using large-scale population genomics data.
Results: By employing genetic instruments as causal anchors, we establish directed associations between gene expression and distant DNA methylation levels, while ensuring specificity of the associations by correcting for linkage disequilibrium and pleiotropy among neighboring genes.