Publications by authors named "R del Gaudio"
Cystic fibrosis (CF) results in chronic pulmonary infections, inflammation, pancreatic insufficiency, and multiple gastrointestinal manifestations. Malnutrition and poor growth are hallmarks of CF, and strongly associated with poor outcomes. Through newborn screening, many infants can be diagnosed within a few days of life, which allows for early initiation of nutritional counseling and close clinical follow-up.
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- Tuberculous paradoxical reaction refers to a worsening of symptoms during effective tuberculosis treatment, distinguishing it from drug resistance and treatment failure.
- The case discussed involves a patient with systemic lupus erythematosus who experienced this reaction in the context of treating tuberculous meningoencephalitis.
- This highlights the complexity of TB treatment in immunocompromised patients and the need for careful monitoring during therapy.
Article Synopsis
- Insulin-like peptide 3 (INSL3) is a key biomarker for Leydig cells in vertebrate testes and plays a crucial role in sperm production by binding to the RXFP2 receptor.
- The study examines the expression of the Insl3 gene and its precursor in both reproductive and non-reproductive tissues, finding low levels of INSL3 in Leydig and germ cells throughout testis development.
- Results indicate that INSL3 has both autocrine and paracrine functions in the testis, and highlight a conserved ligand-receptor interaction mechanism across various vertebrate species.
Background And Purpose: AKB48 is a synthetic cannabinoid illegally sold for its psychoactive cannabis-like effects that have been associated with acute intoxication and whose effects are poorly known.
Experimental Approach: Using a behavioural, neurochemical, and immunohistochemical approach, we investigated the pharmaco-toxicological effects, pharmacokinetics, and neuroplasticity at cannabinoid CB receptors in the cerebellum and cortex induced by repeated AKB48 administration in male and female mice.
Key Results: The effects of AKB48 varied significantly depending on sex and treatment duration.
Article Synopsis
- Burial systems are facing higher costs due to pollution impacts from decomposing bodies, prompting research on decomposition processes in different burial methods.
- The study examined pig carcasses buried in aerated vs. watertight systems, revealing that more insect taxa were found in aerated niches and that aeration promotes better decomposition.
- Findings highlight the role of insects and bacteria in the decomposition process, providing valuable insights for understanding human decomposition, which can aid forensic science in determining post-mortem intervals.