Publications by authors named "R del Carmen Mateos"

Bioplastics are emerging as a promising solution to reduce pollution caused by petroleum-based plastics. Among them, polyhydroxyalkanoates (PHAs) stand out as viable biotechnological alternatives, though their commercialization is limited by expensive downstream processes. Traditional PHA extraction methods often involve toxic solvents and high energy consumption, underscoring the need for more sustainable approaches.

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Introduction: Cognitive impairment and dementia are part of a continuum that progressively leads to functional impairment and dependency. Dementia is a paradigmatic example of chronic and complex psychogeriatric diseases, requiring a comprehensive assessment. The authors underline the importance of implementing a formal assessment of needs (whether met or unmet) as an essential element of comprehensive assessment.

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The KEAP1-NRF2 system plays a crucial role in responding to oxidative and electrophilic stress. Its dysregulation can cause the overexpression of downstream genes, a known cancer hallmark. Understanding and detecting abnormal KEAP1-NRF2 activity is essential for understanding disease mechanisms and identifying therapeutic targets.

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Following the goal of optimizing nutrition, the food industry has been continuously working on food reformulation, nutritional patterns, functional foods development, and the general promotion of a healthy lifestyle. To this end, the scientific community has been increasingly investigating natural compounds that could prevent or treat chronic diseases. Phlorotannins and bromophenols are phenolic compounds particularly present in marine organisms.

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Article Synopsis
  • Ovarian clear cell carcinoma (OCCC) is a tough-to-treat gynecological cancer that shows resistance to chemotherapy, with its underlying mechanisms not fully understood.
  • Recent research combined single-cell analyses and spatial transcriptomics on surgical specimens to identify a resistant subpopulation of OCCC associated with high HIF activity found near cancer-associated fibroblasts (CAFs).
  • The study revealed that the growth factor PDGF contributes to this chemoresistance, and using the drug ripretinib can target CAFs, enhancing the effectiveness of conventional chemotherapy like carboplatin against OCCC.
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