Publications by authors named "R de Vroege"
Magnesium sulphate to prevent perioperative atrial fibrillation in cardiac surgery: a randomized clinical trial : A protocol description of the PeriOperative Magnesium Infusion to Prevent Atrial fibrillation Evaluated (POMPAE) trial.
Trials
August 2024
Article Synopsis
- - The POMPAE trial investigates whether giving continuous intravenous magnesium sulfate before and after cardiac surgery can prevent postoperative atrial fibrillation (POAF), a common and serious complication after such procedures.
- - This phase 2 study involves 530 patients who will be randomly assigned to receive either magnesium or a placebo, with the goal of maintaining specific magnesium levels in the blood.
- - The primary focus is to measure how many patients develop new cases of POAF within the first week after surgery, aiming to provide important insights into reducing adverse outcomes for heart surgery patients.
Background: During cardiac surgery the use of a minimal extracorporeal circulation (MiECC) system may reduce the adverse effects for the patient. This is probably caused by reduced inflammation and hemodilution. For the use of a MiECC circuit, a venous bubble trap (VBT) is warranted for safety reasons.
View Article and Find Full Text PDFSheep are a commonly used and validated model for cardiovascular research and, more specifically, for heart valve research. Implanting a heart valve on the arrested heart in sheep is complex and is often complicated by difficulties in restarting the heart, causing significant on-table mortality. Therefore, optimal cardioprotective management during heart valve implantation in sheep is essential.
View Article and Find Full Text PDFIntroduction: Gaseous microemboli that originate from the cardiopulmonary bypass circuit may contribute to adverse outcome after cardiac surgery. We prospectively evaluated the influence of gaseous microemboli on the release of various biomarkers after use of a minimally invasive extracorporeal technology system.
Methods: In 70 patients undergoing coronary artery bypass grafting with minimized cardiopulmonary bypass, gaseous microemboli were measured intraoperatively with a bubble counter.
Minimally invasive extracorporeal circulation systems are developed to decrease the deleterious effects of cardiopulmonary bypass. For instance, prime volume and foreign surface area are decreased in these systems. However, because of the lack of a venous reservoir in minimized systems, air handling properties of these minimally invasive extracorporeal circulation systems may be decreased as compared to conventional cardiopulmonary bypass systems.
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