Publications by authors named "R de Mutsert"
Article Synopsis
- The review examines how changing sleep timing impacts blood sugar control, pointing out mixed evidence from previous studies.
- It included 14 studies involving 159 adults with either normal or increased weight, showing varying quality and significant effects on glycaemic outcomes.
- The study concludes that delaying sleep can negatively affect blood sugar levels, emphasizing the need for more controlled research on sleep's impact, along with related lifestyle factors.
Background: Obesity may affect an individual's immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.
View Article and Find Full Text PDFArticle Synopsis
- Hypercoagulability is linked to higher levels of coagulation factors and increased thrombin generation, which could be related to type 2 diabetes and other complications like glucose metabolism issues and endothelial dysfunction.
- The study analyzed data from 5,718 participants, tracking diabetes diagnoses over 6.7 years, and found that higher levels of specific coagulation factors correlated with increased risk of developing type 2 diabetes.
- Although glycoprotein acetylation (GlycA) was examined as a potential mediator in these associations, it only explained a small portion of the relationship, suggesting that hypercoagulability plays a significant role in the development of type 2 diabetes.
Article Synopsis
- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
Association Between Low Sex Hormone-Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From Observational and Mendelian Randomization Analyses.
Diabetes
November 2024
The aim of this study was to investigate the associations among sex hormone-binding globulin (SHBG), visceral adipose tissue (VAT), liver fat content, and risk of type 2 diabetes (T2D). In the Netherlands Epidemiology of Obesity study, 5,690 women (53%) and men (47%) without preexisting diabetes were included and followed for incident T2D. SHBG concentrations were measured in all participants, VAT was measured using MRI, and liver fat content was measured using proton magnetic resonance spectroscopy in a random subset of 1,822 participants.
View Article and Find Full Text PDF