Publications by authors named "R de Miguel"
Lattice models are a central idea in statistical thermodynamics, as they allow for the introduction of a configurational entropy by counting the multiplicity of placing indistinguishable particles on a lattice. In this work we use a lattice model to show that the configurational entropy needs to be merged with the molecular translational entropy in order to have a consistent model. This is achieved by replacing the volume of a lattice site with a quantum volume (i.
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- Persistent subcutaneous granulomas develop at the injection site after administering aluminium oxyhydroxide (AlOOH), a common vaccine adjuvant, and can facilitate the infection of macrophages by small ruminant lentiviruses (SRLVs) in sheep.
- The study involved 24 male lambs that underwent vaccination followed by SRLV infection, revealing that the granulomas, initially large, decreased in size over time and exhibited various features including central necrosis and keratin presence.
- The research highlighted significant differences in the expression of the mannose receptor and the restriction factor A3Z1 in relation to the vaccine type and time, suggesting that macrophage polarization might affect SRLV infection, though the overall structure of the granulomas remained
Background: People with HIV-1 (PWH) age differently than the general population. Blood telomere length (BTL) attrition is a surrogate biomarker of immunosenescence and aging in PWH. BTL is reduced immediately after HIV-1 infection and recovers in PWH with long-term virologic suppression, but the extent of this recovery is unknown.
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- Tuberculosis (TB) poses a significant health risk to both humans and non-human primates used in research, especially given the challenges posed by emerging mycobacterial species.
- A natural outbreak of TB was found in imported cynomolgus macaques at AnaPath Research S.A.U. after initial negative tests, leading to extensive screening and diagnosis of the affected animals.
- Despite most macaques showing no symptoms, necropsies confirmed TB in 10 out of 114 animals, tracing the infection back to Asia, while all sanitary measures taken successfully eradicated the disease.
In this work, a polyhedral silsesquioxane (POSS) was used as an engineered drug delivery system for two oxindolimine-copper(II) anticancer complexes, [Cu(isaepy)] and [Cu(isapn)]. The interest in hybrid POSS comes from the necessity of developing materials that can act as adjuvants to improve the cytotoxicity of non-soluble metallodrugs. Functionalization of POSS with a triazole ligand (POSS-atzac) permitted the anchorage of such copper complexes, producing hybrid materials with efficient cytotoxic effects.
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