Synthesis of Carbon 14 and Deuterium-Labelled Nerandomilast (BI 1015550).

(R)-2-(4-(5-Chloropyrimidin-2-yl)piperidin-1-yl)-4-((1-(hydroxymethyl)cyclobutyl)amino)-6,7-dihydrothieno[3,2-d]pyrimidine 5-oxide (BI 1015550, 1) is a potent and selective inhibitor of phosphodiesterase type 4 (PDE4) being developed for the treatment of idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). We report the synthesis of this drug candidate labelled with carbon 14 and deuterium. The carbon 14 synthesis was completed in three radioactive steps in 27% overall yield, with a specific activity of 52 mCi/mmol (1.

Middle Cerebral Artery M2 Occlusions: Impact of Segment Dominance and Benefit of Direct Aspiration for the First-Pass Effect.

Background And Purpose: Endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with M2 segment occlusion of the middle cerebral artery (MCA) is debatable. This study assessed the efficacy, safety, and functional outcomes of EVT in M2 occlusion patients, examining differences in outcomes based on the dominance of the occluded segment (DomM2 vs. Non-DomM2).

Assessment of compliance and therapeutic efficacy of albendazole treatment in Chinese patients with echinococcosis.

Background: Echinococcosis is an infectious parasitic disease that is extremely harmful to human health. Albendazole is provided free of charge to patients requiring medication under the central government finance transfer payment scheme for echinococcosis control and prevention in China. Our aim is to monitor the state of patient medication and its therapeutic impact, which will help improve medication compliance and the therapeutic effect.

One Health governance: theory, practice and ethics.

One Health approach is a global public good (GPG) that invites governance to maximize the health of humans, animals, and the environment by shaping interdisciplinary and cross-sectoral collaboration. This paper explores the theoretical foundations, practical applications, and ethical considerations of the One Health governance architecture. At the theoretical level, One Health governance invites systems thinking and involves collaborative efforts among multiple stakeholders, applying across multi-layered scenarios and requires public-private partnership (PPP).

Transmissibility and control of tuberculosis in school outbreaks: a modeling study based on four outbreaks in China.

Background: The elevated incidence of tuberculosis (TB) outbreaks in schools poses a significant challenge to prevention and control efforts in China. The commonality among most outbreaks is the failure to isolate patients at an early stage. Early isolation of TB cases is crucial for reducing the spread of TB within schools.