Publications by authors named "R al-Ward"
Context: The natural history and malignant potential of cases classified as atypical adrenal masses (AAMs) are unknown.
Objective: To describe the radiological characteristics and clinical outcomes of AAMs.
Design And Participants: A multicenter retrospective study.
Patients And Methods: The primary endpoints were objective response rate (ORR) and disease control rate (DCR). Secondary endpoints were duration of response, blood pressure control, safety, overall and progression-free survival rates, MIBG uptake, and correlations with genetic background.
Results: The study included 25 patients.
Article Synopsis
- Current research indicates that cortisol-secreting adrenocortical carcinoma has a poorer prognosis compared to non-secreting types, but the impact of other secretory subtypes was unclear prior to this study.
- The study analyzed data from 807 patients with adrenocortical carcinoma over 23 years, showing different overall survival rates based on secretory subtype, with cortisol-secreting patients having a median survival of 36 months and non-secreting patients 115 months.
- Mixed cortisol/androgen secreting tumors were linked to worse overall survival, while the type of secretion did not significantly affect survival outcomes in patients who underwent complete resection (R0).
Adrenocortical carcinoma (ACC) is a rare cancer with high recurrence rates and heterogeneous clinical behavior. The role of adjuvant therapy remains unclear because of the challenges in collecting high-quality data for a rare cancer. The current treatment recommendations and guidelines for adjuvant therapy are mostly derived retrospectively from national databases and the treatment outcomes of patients seen in referral centers.
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