Publications by authors named "R Zweiker"
Background: Discordance between coronary angiographic findings and invasive functional significance is well-established. Yet, the prevalence of this mismatch in an era increasingly utilizing invasive functional assessments, such as fractional flow reserve (FFR), remains unclear. This study examines the extent of such discrepancies in current clinical practice.
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- Lipoprotein(a) (Lp(a)) is a genetically determined risk factor for cardiovascular diseases, and its levels can vary widely among individuals.
- A study on 86 patients post-ST elevation myocardial infarction found that Lp(a) levels increased significantly from hospital admission to a 3 to 6 month follow-up, indicating a changing response after the event.
- The research suggests that monitoring Lp(a) levels after a myocardial infarction is important for assessing individual treatment needs based on specific Lp(a) cut-off levels.
Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population.
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- The study investigates how arterial stiffness, measured by pulse wave velocity (PWV), relates to brain health and cognitive function in older adults living in the community.
- Findings indicate that higher PWV is linked to decreased total brain volume, especially during nighttime, and this relationship exists independently of blood pressure levels.
- However, the research did not find significant connections between PWV and markers of cerebral small vessel disease or cognitive impairment.