Accurate and Efficient Numerical Simulation of Land Models Using SUMMA With SUNDIALS.

Numerical simulation of land models without error control can be highly inaccurate. We present the incorporation of the Suite of Nonlinear and Differential-Algebraic Equation Solvers (SUNDIALS) package to solve the equations that simulate thermodynamics and hydrologic processes in the Structure for Unifying Multiple Modeling Alternatives (SUMMA) land model. The algorithmic features of SUNDIALS, such as error estimation and adaptive order and step-size control, result in a SUMMA-SUNDIALS model that delivers substantially improved accuracy and relative computational efficiency compared to integration with the previous SUMMA model, which uses the low-order backward Euler method with no rigorous error control.

Lymphangiogenesis in Odontogenic Keratocysts Compared with Dentigerous Cysts.

Statment Of The Problem: Podoplanin can indicate the lymphangiogenesis. On the other hand, lymphangiogenesis affects the biological behavior of lesions. The clinical behavior of odontogenic keratocysts (OKC) and dentigerous cysts (DC) is different.

Outcomes of chronic total occlusion percutaneous coronary intervention from the RAIAN (RAjaie - Iran) registry.

Objective: While most of the evidence in CTO interventions emerge from Western and Japanese studies, few data have been published up today from the Middle East. Objective of this study was to evaluate technical success rates and clinical outcomes of an Iranian population undergoing CTO PCI in a tertiary referral hospital. Moreover, we sought to evaluate the efficacy of our CTO teaching program.

Dual-targeted delivery system using hollow silica nanoparticles with H-triggered bubble generating characteristic coated with hyaluronic acid and AS1411 for cancer therapy.

Objective: Herein, a dual-targeting delivery system using mesoporous silica nanoparticles with hollow structures (HMSNs) was developed for the specific delivery of epirubicin (EPI) to cancer cells and introducing a H-triggered bubble generating nanosystem (BGNS). HMSNs containing EPI are covered by hyaluronic acid (HA) shell and AS1411 aptamer to create the BGNS-EPI-HA-Apt complex, which is highly selective against CD44 marker and nucleolin overexpressed on the surface of tumor cells.

Methods: MTT assay compared the cytotoxicity of different treatments in CHO (Chinese hamster ovary) cells as well as 4T1 (murine mammary carcinoma) and MCF-7 (human breast adenocarcinoma) cells.

Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β () Gene in Hepatocytes.

HNF4α, a member of the nuclear receptor superfamily, regulates the genes involved in lipid and glucose metabolism. The expression of the gene in the liver of HNF4α knock-out mice was higher versus wildtype controls, whereas oppositely, promoter activity was 50% reduced by the overexpression of HNF4α in HepG2 cells, and treatment with retinoic acid (RA), a major metabolite of vitamin A, increased promoter activity 15-fold. The human promoter contains two DR5 and one DR8 binding motifs, as RA response elements (RARE) proximal to the transcription start site.