Publications by authors named "R Ziganshin"
Bgl2p is a major, conservative, constitutive glucanosyltransglycosylase of the yeast cell wall (CW) with amyloid amino acid sequences, strongly non-covalently anchored in CW, but is able to leave it. In the environment, Bgl2p can form fibrils and/or participate in biofilm formation. Despite a long study, the question of how Bgl2p is anchored in CW remains unclear.
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- Dermal fibroblasts (DFs) from hypertrophic scars (HTSFs) show higher proliferation and motility compared to those from normal skin (NDFs), despite minor karyotype differences.
- A detailed proteomic analysis revealed unique metabolic proteins in HTSFs that could explain their aggressive behavior and links to scarring.
- Identified proteins related to cell growth, movement, fibrosis, and inflammation suggest potential targets for future treatments or prevention strategies for skin scarring.
New Recessive Dystrophic Epidermolysis Bullosa intermediate variant resulting from alternative splicing of exon 19 and truncation in FN III-like domain of type VII collagen.
Aleksandra A Martynova Alexey A Kubanov Nadezhda A Evtushenko Anastasiya V Kosykh Nikolay V Kondratyev Rustam H Ziganshin
Br J Dermatol
October 2024
Article Synopsis
- Membrane-associated 70 kDa heat shock protein (mHsp70) plays a crucial role in the migration and invasion of malignant brain tumor cells, as observed in patient samples.
- Advanced techniques like inverted confocal microscopy and mass spectrometry showed that mHsp70 is prominently expressed on the surface of cancer cells, particularly in areas surrounding the tumors.
- Inhibiting HSP70 with small molecules significantly reduced cancer cell invasiveness and delayed tumor progression in animal models, suggesting that targeting mHsp70 could be a promising strategy for developing new cancer therapies.